Calcium-dependent hydrolysis of supported planar lipids was triggered by honey bee venom phospholipase A2 with the right orientation at the interface

被引：14

作者：

Kai, Siqi ^{[1
]}

Li, Xu ^{[1
]}

Li, Bolin ^{[1
]}

Han, Xiaofeng ^{[1
]}

Lu, Xiaolin ^{[1
]}

机构：

[1] Southeast Univ, Sch Biol Sci & Med Engn, State Key Lab Bioelect, Nanjing 210096, Jiangsu, Peoples R China

来源：

PHYSICAL CHEMISTRY CHEMICAL PHYSICS | 2018年 / 20卷 / 01期

基金：

中国国家自然科学基金;

关键词：

ATOMIC-FORCE MICROSCOPY; FUNCTIONAL PERSPECTIVE; COMPETITIVE-INHIBITION; STRUCTURAL-ANALYSIS; BINDING; ACTIVATION; CATALYSIS; BILAYER; SITE; SPECTROSCOPY;

D O I：

10.1039/c7cp06344j

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Hydrolysis of planar phospholipids catalyzed by honey bee venom phospholipase A(2) (bvPLA(2)) was studied. Experiments demonstrated that Ca2+ ions mediated between the lipids and bvPLA(2), induced reorientation of bvPLA(2), and activated hydrolysis. One of the hydrolysis products, fatty acids, was desorbed, and the other one, lysophospholipids, self-organized at the interface.

引用

页码：63 / 67

页数：5

共 36 条

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