Monitoring the fidelity of mitotic chromosome segregation by the spindle assembly checkpoint

被引：55

作者：

Silva, P. ^{[1
]}

Barbosa, J. ^{[1
]}

Nascimento, A. V. ^{[1
]}

Faria, J. ^{[1
]}

Reis, R. ^{[1
]}

Bousbaa, H. ^{[1
]}

机构：

[1] CESPU, Inst Super Ciencias Saude Norte, CICS, P-4585116 Gandra Prd, Portugal

来源：

CELL PROLIFERATION | 2011年 / 44卷 / 05期

关键词：

KINETOCHORE-MICROTUBULE INTERACTIONS; SMALL-MOLECULE INHIBITOR; CANCER-CELLS; CYTOPLASMIC DYNEIN; MAD2; ACTIVATION; BI-ORIENTATION; COMPLEX; TENSION; BUBR1; ATTACHMENT;

D O I：

10.1111/j.1365-2184.2011.00767.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Accurate chromosome segregation relies on activity of the spindle assembly checkpoint, a surveillance mechanism that prevents premature anaphase onset until all chromosomes are properly attached to the mitotic spindle apparatus and aligned at the metaphase plate. Defects in this mechanism contribute to chromosome instability and aneuploidy, a hallmark of malignant cells. Here, we review the molecular mechanisms of activation and silencing of the spindle assembly checkpoint and its relationship to tumourigenesis.

引用

页码：391 / 400

页数：10

共 50 条

[1] Mitotic spindle assembly and chromosome segregation: Refocusing on microtubule dynamics
Kline-Smith, SL
Walczak, CE
MOLECULAR CELL, 2004, 15 (03) : 317 - 327
[2] Spindle assembly checkpoint regulation of chromosome segregation in mammalian oocytes
Polanski, Zbigniew
REPRODUCTION FERTILITY AND DEVELOPMENT, 2013, 25 (03) : 472 - 483
[3] The spindle checkpoint and chromosome segregation in meiosis
Gorbsky, Gary J.
FEBS JOURNAL, 2015, 282 (13) : 2458 - 2474
[4] Regulators of chromosome movement and the mitotic spindle checkpoint
Gorbsky, Gary J.
Kallio, Marko J.
Emanuele, Michael J.
Stukenberg, P. Todd
Vorozhko, Valeriya V.
FASEB JOURNAL, 2007, 21 (05): : A209 - A209
[5] Regulation of mitotic progression by the spindle assembly checkpoint
Lischetti, Tiziana
Nilsson, Jakob
MOLECULAR & CELLULAR ONCOLOGY, 2015, 2 (01)
[6] Absence of the Spindle Assembly Checkpoint Restores Mitotic Fidelity upon Loss of Sister Chromatid Cohesion
Silva, Rui D.
Mirkovic, Mihailo
Guilgur, Leonardo G.
Rathore, Om S.
Martinho, Rui Goncalo
Oliveira, Raquel A.
CURRENT BIOLOGY, 2018, 28 (17) : 2837 - +
[7] Balanced Activity of Three Mitotic Motors Is Required for Bipolar Spindle Assembly and Chromosome Segregation
van Heesbeen, Roy G. H. P.
Tanenbaum, Marvin E.
Medema, Rene H.
CELL REPORTS, 2014, 8 (04): : 948 - 956
[8] Spindle checkpoint-independent inhibition of mitotic chromosome segregation by Drosophila Mps1
Althoff, Friederike
Karess, Roger E.
Lehner, Christian F.
MOLECULAR BIOLOGY OF THE CELL, 2012, 23 (12) : 2275 - 2291
[9] CENP-C is involved in chromosome segregation, mitotic checkpoint function, and kinetochore assembly
Kwon, Mi-Sun
Hori, Tetsuya
Okada, Masahiro
Fukagawa, Tatsuo
MOLECULAR BIOLOGY OF THE CELL, 2007, 18 (06) : 2155 - 2168
[10] SAC-ing mitotic errors: How the spindle assembly checkpoint (SAC) plays defense against chromosome mis-segregation
Kadura, S
Sazer, S
CELL MOTILITY AND THE CYTOSKELETON, 2005, 61 (03): : 145 - 160

← 1 2 3 4 5 →