14-3-3 Proteins in Echinococcus:: Their role and potential as protective antigens

被引：38
|
作者：
Siles-Lucas, Mar [1 ]
Merli, Michael [2 ]
Gottstein, Bruno [3 ]
机构：
[1] CSIC, IRNASA, Unidad Patol Anim, Salamanca 37008, Spain
[2] Univ Hohenheim, Dept Parasitol, D-7000 Stuttgart, Germany
[3] Univ Bern, Inst Parasitol, CH-3001 Bern, Switzerland
来源：
EXPERIMENTAL PARASITOLOGY | 2008年 / 119卷 / 04期
关键词：
cestoda; Echinococcus; 14-3-3;
D O I：
10.1016/j.exppara.2008.01.009
中图分类号：
R38 [医学寄生虫学]; Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ; 100103 ;
摘要：
14-3-3 Proteins are a family of highly conserved proteins among all eukaryotic organisms studied so far. As basically intracellular proteins, they play a key role in basic cellular events related to cellular proliferation, including signal transduction, cell-cycle control, cell differentiation and cell survival. The 14-3-3 proteins have been described and characterized in several parasites, and mostly studied in Echinocuccus granulosus and Echinocuccus multilocularis. Here, we review the discoveries regarding this protein family in the genus Echinococcus, describing new data about specific aspects related with their implication in the parasite biology and immunology in the frame of the host-parasite relationship. (C) 2008 Elsevier Inc. All rights reserved.
引用
收藏
页码：516 / 523
页数：8
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