Fragment-based lead design

被引：16

作者：

Tarasova, Olga A. ^{[1
]}

Poroikov, V. V. ^{[1
]}

机构：

[1] Russian Acad Med Sci, VN Orekhovich Inst Biomed Chem, Ul Pogodinskaya 10, Moscow 119121, Russia

来源：

RUSSIAN CHEMICAL REVIEWS | 2012年 / 81卷 / 02期

关键词：

DE-NOVO DESIGN; SURFACE-PLASMON RESONANCE; FOCUSED LIBRARY DESIGN; X-RAY CRYSTALLOGRAPHY; DYNAMIC LIGAND DESIGN; DRUG-LIKE MOLECULES; GENETIC ALGORITHM; ORGANIC-SYNTHESIS; IN-SILICO; COMBINATORIAL CHEMISTRY;

D O I：

10.1070/RC2012v081n02ABEH004222

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

State-of-the-art approaches to the fragment-based design of organic compounds with desired properties are considered. The review covers methods, which are used in different steps of the design, such as computational methods for fragment library design, experimental and computational methods for fragment discovery and methods for the generation of structures of organic compounds. Examples are given of drug candidates, which were constructed using the fragment-based approach. The bibliography includes 156 references.

引用

页码：158 / 174

页数：17

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