Regulation of PAI-1 expression by genetic polymorphisms - Impact on atherogenesis

被引：45
|
作者：
Nordt, TK [1 ]
Lohrmann, J [1 ]
Bode, C [1 ]
机构：
[1] Univ Freiburg, Dept Cardiol, Freiburg, Germany
来源：
THROMBOSIS RESEARCH | 2001年 / 103卷
关键词：
plasminogen activator inhibitor; polymorphisms; arteriosclerosis; cardiovascular disease;
D O I：
10.1016/S0049-3848(01)00292-4
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Increased expression of plasminogen activator inhibitor type 1 (PAI-1) is now considered as an independent risk factor for cardiovascular disease. Numerous biochemical factors have been found to regulate the expression of PAI-1 gene and the synthesis of PAI-1 protein. In the recent past, polymorphisms in the PAI-1 gene have been identified and their impact on PAI-1 expression has been characterized. This article will review the current knowledge of these PAI-1 gene polymorphisms (in cell culture, epidemiological, and clinical studies) and their role in the development of cardiovascular disease. (C) 2001 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：S1 / S5
页数：5
相关论文
共 50 条
  • [21] Regulation of PAI-1 in obesity and insulin resistance
    Juhan-Vague, I
    Alessi, MC
    Morange, P
    ATHEROSCLEROSIS, 1999, 144 : 14 - 14
  • [22] GENOTYPE-SPECIFIC REGULATION OF PAI-1 EXPRESSION BY HYPERTRIGLYCERIDEMIC VLDL IN PAI-1 GENOTYPED CULTURED HUMAN ENDOTHELIAL-CELL TYPES
    LI, XN
    GRENETT, HE
    BENZA, RL
    BRADLEY, WA
    GIANTURCO, SH
    GRAMMER, JR
    TABENGWA, EM
    GAY, CP
    BOOYSE, FM
    CIRCULATION, 1995, 92 (08) : 3332 - 3332
  • [23] Regulation of PAI-1 gene expression by CLOCK, a component of the molecular clock, in adipocytes
    Tanaka, Atsuko
    Oishi, Katsutaka
    Ohkura, Naoki
    Kanai, Shiho
    Matsuda, Juzo
    Ishida, Norio
    Atsumi, Gen-ichi
    YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, 2007, 127 : 40 - 40
  • [24] Studies of eNOS and PAI-1 genetic polymorphisms in Brazilian young adults with cardiovascular disease.
    Hirata, MH
    Sampaio, MF
    Santos, FC
    Hirata, RD
    Picciotti, R
    Armaganijan, D
    Batlouni, M
    CLINICAL CHEMISTRY, 2005, 51 : A191 - A191
  • [25] PAI-1 polymorphism and expression of uPA, PAI-1 and COX-2 in breast cancer.
    Minisini, AM
    Di Loreto, C
    Pestrin, M
    Fabbro, D
    Cardellino, GG
    Russo, S
    Andreetta, C
    Damante, G
    Piga, A
    Puglisi, F
    JOURNAL OF CLINICAL ONCOLOGY, 2005, 23 (16) : 879S - 879S
  • [26] Abnormal expression of uPA and PAI-1 in lymphangioleiomyomatosis
    Zhe, X
    Schuger, L
    MOLECULAR BIOLOGY OF THE CELL, 2004, 15 : 424A - 424A
  • [27] THROMBOMODULIN AND PAI-1 EXPRESSION IN RECURRENT MISCARRIAGE
    Papamitsou, T.
    Sioga, A.
    Papadopoulou, K.
    Toskas, A.
    Hatzistamatiou, M.
    Papadopoulou, C.
    Kiskinidou, S.
    Economou, L.
    BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY, 2011, 109 : 100 - 100
  • [28] ACE and PAI-1 gene polymorphisms in renal transplant recipients
    Cristallo, A. F.
    Fiordoro, S.
    Rosetta, P.
    Paolucci, I.
    Santori, G.
    Fontana, I.
    Tagliamacco, A.
    Bertani, G.
    Nocera, A.
    Valente, U.
    Barocci, S.
    TISSUE ANTIGENS, 2011, 77 (05): : 445 - 445
  • [29] Differential regulation of PAI-1 gene expression in human fibroblasts predisposed to a fibrotic phenotype
    Higgins, PJ
    Slack, JK
    Diegelmann, RF
    Staiano-Coico, L
    EXPERIMENTAL CELL RESEARCH, 1999, 248 (02) : 634 - 642
  • [30] Expression of PAI-1 in human visceral and subcutaneous fat and its correlation with blood plasma PAI-1 levels
    Polac, I
    Cierniewska-Cieslak, A
    Pertynski, T
    Szylo, K
    Cierniewski, CS
    THROMBOSIS AND HAEMOSTASIS, 1999, : 783 - 784
12345