Regulation of PAI-1 expression by genetic polymorphisms - Impact on atherogenesis

被引：45
|
作者：
Nordt, TK [1 ]
Lohrmann, J [1 ]
Bode, C [1 ]
机构：
[1] Univ Freiburg, Dept Cardiol, Freiburg, Germany
来源：
THROMBOSIS RESEARCH | 2001年 / 103卷
关键词：
plasminogen activator inhibitor; polymorphisms; arteriosclerosis; cardiovascular disease;
D O I：
10.1016/S0049-3848(01)00292-4
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Increased expression of plasminogen activator inhibitor type 1 (PAI-1) is now considered as an independent risk factor for cardiovascular disease. Numerous biochemical factors have been found to regulate the expression of PAI-1 gene and the synthesis of PAI-1 protein. In the recent past, polymorphisms in the PAI-1 gene have been identified and their impact on PAI-1 expression has been characterized. This article will review the current knowledge of these PAI-1 gene polymorphisms (in cell culture, epidemiological, and clinical studies) and their role in the development of cardiovascular disease. (C) 2001 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：S1 / S5
页数：5
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