Autoimmunity and coxsackievirus infection in primary Sjogren's syndrome

被引：18
|
作者：
Triantafyllopoulou, A
Moutsopoulos, HM
机构：
[1] Natl Univ Athens, Sch Med, Dept Pathophysiol, GR-11527 Athens, Greece
[2] Montefiore Med Ctr, Albert Einstein Coll Med, Dept Med, Bronx, NY 10467 USA
来源：
AUTOIMMUNITY: CONCEPTS AND DIAGNOSIS AT THE CUTTING EDGE | 2005年 / 1050卷
关键词：
Sjogren's syndrome; autoimmunity; coxsackieviruses; epithelial cell activation;
D O I：
10.1196/annals.1313.090
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Exocrine gland epithelial cells are the target of autoimmune pathology in primary Sjogren's syndrome (pSS). Their activated phenotype has incited the notion that they are infected by a virus. We recently presented evidence that coxsackieviruses may persistently infect the salivary glands of pSS patients. We hypothesize that coxsackieviruses may play a permissive role for the perpetuation and possibly the induction of autoimmune disease in pSS.
引用
收藏
页码：389 / 396
页数：8
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