A PVA/PVP hydrogel for human lens substitution: Synthesis, rheological characterization, and in vitro biocompatibility

被引：39
|
作者：
Leone, Gemma [1 ]
Consumi, Marco [1 ]
Greco, Giuseppe [2 ]
Bonechi, Claudia [1 ,3 ]
Lamponi, Stefania [1 ]
Rossi, Claudio [1 ,3 ]
Magnani, Agnese [1 ]
机构：
[1] Univ Siena, Dept Pharmaceut & Appl Chem, I-53100 Siena, Italy
[2] Casa Cura Rugani, I-53100 Siena, Italy
[3] Interuniv Ctr Colloid & Surface Sci, CSGI, I-50019 Sesto Fiorentino, FI, Italy
来源：
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS | 2011年 / 97B卷 / 02期
关键词：
human crystalline lens; rheology; hydrogel; poly(vinyl alcohol); poly(N-vinyl-2-pyrrolidinone); ACCOMMODATING INTRAOCULAR LENSES; MAGNETIC-RESONANCE-SPECTROSCOPY; HUMAN CRYSTALLINE LENS; DIFFUSION-COEFFICIENTS; MECHANICAL-PROPERTIES; PFG-NMR; CAPSULE; AGE; CARBOXYMETHYLCELLULOSE; TRIMETAPHOSPHATE;
D O I：
10.1002/jbm.b.31813
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
To overcome opacification and absence of accommodation of human lens substitutes a new poly(vinyl alcohol) (PVA)/poly(N-vinyl-2- pyrrolidinone) (PVP) based hydrogel (PPS31075) was realised. The Infrared Spectroscopy and the mechanical spectra confirmed the successful occurrence of crosslinking reaction. The rheological analysis pointed out a behavior comparable with that of young human lens in terms of complex shear modulus and accommodation capability. Further analysis in terms of optical properties, water content measurements, diffusion coefficient, cytotoxicity, and human capsular cell adhesion confirmed the applicability of such a hydrogel as potential human lens substitute. (C) 2011 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 978: 278-288, 2011.
引用
收藏
页码：278 / 288
页数：11
相关论文
共 50 条
  • [31] Hydrogel-forming agar-graft-PVP and κ-carrageenan-graft-PVP blends:: Rapid synthesis and characterization
    Prasad, Kamalesh
    Mehta, Gaurav
    Meena, Ramavatar
    Siddhanta, A. K.
    JOURNAL OF APPLIED POLYMER SCIENCE, 2006, 102 (04) : 3654 - 3663
  • [32] Characterization and quantitation of PVP content in a silicone hydrogel contact lens produced by dual-phase polymerization processing
    Hoteling, Andrew J.
    Nichols, William F.
    Harmon, Patricia S.
    Conlon, Shawn M.
    Nunez, Ivan M.
    Hoff, Joseph W.
    Cabarcos, Orlando M.
    Steffen, Robert B.
    Hook, Daniel J.
    JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS, 2018, 106 (03) : 1064 - 1072
  • [33] In vitro assessment of the biocompatibility of chemically treated silicone materials with human lens epithelial cells
    Elizabeth C. Y. Kao
    Junghee Seo
    David J. McCanna
    Lakshman N. Subbaraman
    Lyndon W. Jones
    Scientific Reports, 12
  • [34] In vitro assessment of the biocompatibility of chemically treated silicone materials with human lens epithelial cells
    Kao, Elizabeth C. Y.
    Seo, Junghee
    McCanna, David J.
    Subbaraman, Lakshman N.
    Jones, Lyndon W.
    SCIENTIFIC REPORTS, 2022, 12 (01)
  • [35] Synthesis, characterization, and their some chemical and biological properties of PVA/PAA/nPS hydrogel nanocomposites: Hydrogel and wound dressing
    Diken, Mehmet Emin
    Kizilduman, Berna Kocer
    Kardas, Begumhan Yilmaz
    Dogan, Enes Emre
    Dogan, Mehmet
    Turhan, Yasemin
    Dogan, Serap
    JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS, 2020, 35 (03) : 203 - 215
  • [36] Synthesis, Characterization and In Vitro Biocompatibility Studies of Levonorgestrel-Loaded Nanocomposites
    Lv, Fang
    Li, Xueli
    Huang, Xiaman
    Liu, Kaifeng
    Pan, Yu
    Ji, Yurong
    Qian, Yang
    Wei, Mian
    Gu, Fangle
    Wang, Daxin
    Zhang, Xiaomei
    JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY, 2017, 17 (03) : 2098 - 2103
  • [37] Semifluorinated symmetrical diethers for intraocular use:: Synthesis, characterization, and in vitro biocompatibility
    Dinkelmann, S
    Geister, U
    Röhlke, W
    Meinert, H
    Northoff, H
    ARTIFICIAL CELLS BLOOD SUBSTITUTES AND BIOTECHNOLOGY, 2001, 29 (01): : 71 - 83
  • [38] Synthesis and characterization of biomass lignin-based PVA super-absorbent hydrogel
    Wu, Linjun
    Huang, Siqi
    Zheng, Jia
    Qiu, Zhongjie
    Lin, Xuliang
    Qin, Yanlin
    INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2019, 140 : 538 - 545
  • [39] Synthesis and Characterization of Magnetic Polyvinyl Alcohol (PVA) Hydrogel Microspheres for the Embolization of Blood Vessel
    Qiu, Shuang
    Ge, Nai J.
    Sun, Dong K.
    Zhao, Sheng
    Sun, Jian F.
    Guo, Zhao B.
    Hu, Ke
    Gu, Ning
    IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING, 2016, 63 (04) : 730 - 736
  • [40] Synthesis and in vitro antimicrobial characterization of Boron-PVA Electrospun nanofibers
    Isik, Ahmet Fatih
    Keskin, Nalan Oya San
    Ulcay, Yusuf
    JOURNAL OF THE TEXTILE INSTITUTE, 2019, 110 (04) : 575 - 580
12345