A PVA/PVP hydrogel for human lens substitution: Synthesis, rheological characterization, and in vitro biocompatibility

被引：39
|
作者：
Leone, Gemma [1 ]
Consumi, Marco [1 ]
Greco, Giuseppe [2 ]
Bonechi, Claudia [1 ,3 ]
Lamponi, Stefania [1 ]
Rossi, Claudio [1 ,3 ]
Magnani, Agnese [1 ]
机构：
[1] Univ Siena, Dept Pharmaceut & Appl Chem, I-53100 Siena, Italy
[2] Casa Cura Rugani, I-53100 Siena, Italy
[3] Interuniv Ctr Colloid & Surface Sci, CSGI, I-50019 Sesto Fiorentino, FI, Italy
来源：
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS | 2011年 / 97B卷 / 02期
关键词：
human crystalline lens; rheology; hydrogel; poly(vinyl alcohol); poly(N-vinyl-2-pyrrolidinone); ACCOMMODATING INTRAOCULAR LENSES; MAGNETIC-RESONANCE-SPECTROSCOPY; HUMAN CRYSTALLINE LENS; DIFFUSION-COEFFICIENTS; MECHANICAL-PROPERTIES; PFG-NMR; CAPSULE; AGE; CARBOXYMETHYLCELLULOSE; TRIMETAPHOSPHATE;
D O I：
10.1002/jbm.b.31813
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
To overcome opacification and absence of accommodation of human lens substitutes a new poly(vinyl alcohol) (PVA)/poly(N-vinyl-2- pyrrolidinone) (PVP) based hydrogel (PPS31075) was realised. The Infrared Spectroscopy and the mechanical spectra confirmed the successful occurrence of crosslinking reaction. The rheological analysis pointed out a behavior comparable with that of young human lens in terms of complex shear modulus and accommodation capability. Further analysis in terms of optical properties, water content measurements, diffusion coefficient, cytotoxicity, and human capsular cell adhesion confirmed the applicability of such a hydrogel as potential human lens substitute. (C) 2011 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 978: 278-288, 2011.
引用
收藏
页码：278 / 288
页数：11
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