Synthesis of 3-carboxylic derivatives of 1,5-benzodiazepines

被引：2

作者：

Mansour, O

Szymonski, B

Thomasson, F

Morand, JM

Cussac, M ^{[1
]}

机构：

[1] Univ Grenoble 1, Fac Pharm, CNRS,UMR 5063, Dept Pharmacochim Mol,Lab Chim Therapeut, F-38706 La Tronche, France

[2] Univ Grenoble 1, Fac Pharm, CNRS,UMR 5063, Dept Pharmacochim Mol,Serv Commun,RMN, F-38706 La Tronche, France

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 2001年 / 38卷 / 03期

关键词：

D O I：

10.1002/jhet.5570380315

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A series of 3-carboxylic derivatives of disubstituted 1,5-benzodiazepines (5-9) was synthesized by heterocyclisation from 1,2-diaminobenzene (1) with dibenzoylmethane (2) followed by bromination on position 3 and by introduction of the carboxylic group or introduction of the malonic moiety. Reduction of the heterocycle gave the perhydro derivative diethyl (2,4-diphenyl-1,2,4,5-tetrahydro-3H-1,5-benzodiazepin-3-yl)malonate (9).

引用

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页码：641 / 643

页数：3

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