A simple, convenient preparation for enantiomerically pure 1,1′-bi-2-naphthols

被引：39
|
作者：
Shan, ZX [1 ]
Xiong, Y [1 ]
Li, WZ [1 ]
Zhao, DJ [1 ]
机构：
[1] Wuhan Univ, Dept Chem, Wuhan 430072, Peoples R China
来源：
TETRAHEDRON-ASYMMETRY | 1998年 / 9卷 / 22期
基金：
中国国家自然科学基金;
关键词：
D O I：
10.1016/S0957-4166(98)00396-6
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
A new preparative method for enantiomerically pure 1,1'-bi-2-naphthols is described. 1,1'-Bi-2-naphtholboric anhydride generated from the reaction of racemic 1,1'-bi-2-naphthol and boric acid in toluene is reacted with (S)-proline to produce 1,1'-bi-2-naphtholboric proline anhydride. Its two diastereomers were efficiently separated in THE After treating successively with NaOH, HCl, and recrystallizing from benzene, enantiomerically pure (S)and (R)-1,1'-bi-2-naphthol were obtained in 71-79% yield and in 62-74% yield, respectively. (C) 1998 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：3985 / 3989
页数：5
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