Miniature endoscope for simultaneous optical coherence tomography and laser-induced fluorescence measurement

被引：97
|
作者：
Tumlinson, AR
Hariri, LP
Utzinger, U
Barton, JK
机构：
[1] Univ Arizona, Ctr Opt Sci, Tucson, AZ 85721 USA
[2] Univ Arizona, Div Biomed Engn, Tucson, AZ 85721 USA
来源：
APPLIED OPTICS | 2004年 / 43卷 / 01期
关键词：
D O I：
10.1364/AO.43.000113
中图分类号：
O43 [光学];
学科分类号：
070207 ; 0803 ;
摘要：
We have designed a multimodality system that combines optical coherence tomography (OCT) and laser-induced fluorescence (LIF) in a 2.0-mm-diameter endoscopic package. OCT provides similar to18-mum resolution cross-sectional structural information over a 6-mm field. LIF spectra are collected sequentially at submillimeter resolution across the same field and provide histochemical. information about the tissue. We present the use of a rod prism to reduce the asymmetry in the OCT beam caused by a cylindrical window. The endoscope has been applied to investigate mouse colon cancer in vivo. (C) 2004 Optical Society of America.
引用
收藏
页码：113 / 121
页数：9
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