Electrospun Scaffold of Collagen and Polycaprolactone Containing ZnO Quantum Dots for Skin Wound Regeneration

被引：36
|
作者：
Li, Pengfei [1 ]
Ruan, Liming [2 ]
Wang, Ruofan [1 ,2 ]
Liu, Tianqi [1 ]
Song, Gao [1 ]
Gao, Xiaofei [1 ]
Jiang, Guohua [1 ,3 ,4 ]
Liu, Xiaoyan [5 ]
机构：
[1] Zhejiang Sci Tech Univ, Sch Mat Sci & Engn, Hangzhou 310018, Peoples R China
[2] Beilun Peoples Hosp Ningbo City, Dept Dermatol, Ningbo 315800, Peoples R China
[3] Zhejiang Sci Tech Univ, Zhejiang Mauritius Joint Res Ctr Biomat & Tissue, Hangzhou 310018, Peoples R China
[4] Zhejiang Sci Tech Univ, Inst Smart Biomed Mat, Hangzhou 310018, Peoples R China
[5] Zhejiang Univ, Affiliated Hosp 1, Dept Dermatol, Hangzhou 310003, Peoples R China
来源：
JOURNAL OF BIONIC ENGINEERING | 2021年 / 18卷 / 06期
基金：
中国国家自然科学基金;
关键词：
Wound dressing; Issue engineering scaffold; Wound healing; Electrospun nanofibers; IN-VIVO; ANTIBACTERIAL; NANOPARTICLES; NANOFIBERS; ZINC; PROGRESS; THERAPY; FIBERS;
D O I：
10.1007/s42235-021-00115-7
中图分类号：
T [工业技术];
学科分类号：
08 ;
摘要：
Nanofibers (NFs) have been widely used in tissue engineering such as wound healing. In this work, the antibacterial ZnO quantum dots (ZnO QDs) have been incorporated into the biocompatible poly (epsilon-caprolactone)/collagen (PCL/Col) fibrous scaffolds for wound healing. The as-fabricated PCL-Col/ZnO fibrous scaffolds exhibited good swelling, antibacterial activity, and biodegradation behaviors, which were beneficial for the applications as a wound dressing. Moreover, the PCL-Col/ZnO fibrous scaffolds showed excellent cytocompatibility for promoting cell proliferation. The resultant PCL-Col/ZnO fibrous scaffolds containing vascular endothelial growth factor (VEGF) also exhibited promoted wound-healing effect through promoting expression of transforming growth factor-beta (TGF-beta) and the vascular factor (CD31) in tissues in the early stages of wound healing. This new electrospun fibrous scaffolds with wound-healing promotion and antibacterial property should be convenient for treating wound healing.
引用
收藏
页码：1378 / 1390
页数：13
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