Current Status and Prospects of Targeted Therapy for Osteosarcoma

被引：54

作者：

Hu, Zunguo ^{[1
]}

Wen, Shuang ^{[1
]}

Huo, Zijun ^{[2
]}

Wang, Qing ^{[3
]}

Zhao, Jiantao ^{[2
]}

Wang, Zihao ^{[1
]}

Chen, Yanchun ^{[2
]}

Zhang, Lingyun ^{[3
]}

Zhou, Fenghua ^{[3
]}

Guo, Zhangyu ^{[3
]}

Liu, Huancai ^{[1
]}

Zhou, Shuanhu ^{[4
]}

机构：

[1] Weifang Med Univ, Affiliated Hosp, Sch Clin Med, Dept Joint Surg, Weifang 261061, Peoples R China

[2] Weifang Med Univ, Sch Basic Med Sci, Dept Histol & Embryol, Weifang 261053, Peoples R China

[3] Weifang Med Univ, Neurol Disorders & Regenerat Repair Lab, Weifang 261053, Peoples R China

[4] Harvard Med Sch, Brigham & Womens Hosp, Dept Orthped Surg, Boston, MA 02115 USA

来源：

CELLS | 2022年 / 11卷 / 21期

关键词：

osteosarcoma; targeted therapy; chemotherapy; surgical treatment; HIGH-GRADE OSTEOSARCOMA; GROWTH-FACTOR RECEPTOR; SOFT-TISSUE SARCOMAS; FACTOR-I RECEPTOR; PHASE-II; METASTATIC OSTEOSARCOMA; PHOTODYNAMIC THERAPY; PROGNOSTIC-FACTORS; LIMB SALVAGE; CANCER;

D O I：

10.3390/cells11213507

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Osteosarcoma (OS) is a highly malignant tumor occurring in bone tissue with a high propensity to metastasize, and its underlying mechanisms remain largely elusive. The OS prognosis is poor, and improving the survival of OS patients remains a challenge. Current treatment methods such as surgical approaches, chemotherapeutic drugs, and immunotherapeutic drugs remain ineffective. As research progresses, targeted therapy is gradually becoming irreplaceable. In this review, several treatment modalities for osteosarcoma, such as surgery, chemotherapy, and immunotherapy, are briefly described, followed by a discussion of targeted therapy, the important targets, and new technologies for osteosarcoma treatment.

引用

页数：19

共 50 条

[21] CURRENT STATUS AND FUTURE PROSPECTS FOR BIOLOGICS THERAPY OF SPA
Landewe, R.
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY, 2010, 28 (04) : 600 - 600
[22] Current Status and Prospects of Gene Therapy for the Inner Ear
Sun, Hong
Huang, Aji
Cao, Shousong
HUMAN GENE THERAPY, 2011, 22 (11) : 1311 - 1322
[23] Oncolytic adenoviruses in anticancer therapy: Current status and prospects
Svyatchenko, V. A.
Tarasova, M. V.
Netesov, S. V.
Chumakov, M.
MOLECULAR BIOLOGY, 2012, 46 (04) : 496 - 507
[24] Interferon: Current Status and Future Prospects in Cancer Therapy
Wang, Ben X.
Rahbar, Ramtin
Fish, Eleanor N.
JOURNAL OF INTERFERON AND CYTOKINE RESEARCH, 2011, 31 (07): : 545 - 552
[25] EDITORIAL: Gene Therapy for Cancer: Current Status and Prospects
Gregory P. Kouraklis
Digestive Diseases and Sciences, 2003, 48 : 854 - 855
[26] Oncolytic adenoviruses in anticancer therapy: Current status and prospects
V. A. Svyatchenko
M. V. Tarasova
S. V. Netesov
P. M. Chumakov
Molecular Biology, 2012, 46 : 496 - 507
[27] Targeted induction of apoptosis for cancer therapy: current progress and prospects
Bremer, Edwin
van Dam, Go
Kroesen, Bart Jan
de Leij, Lou
Helfrich, Wijnand
TRENDS IN MOLECULAR MEDICINE, 2006, 12 (08) : 382 - 393
[28] Current status and future prospects of human gene therapy
Shimada, T
ACTA PAEDIATRICA JAPONICA, 1996, 38 (02): : 176 - 181
[29] Current status and prospects of nanosuspension for improved transdermal targeted drug delivery
Yang, Chongzhao
Wang, Wenlu
Xue, Linying
Wang, Yancai
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, 2024, 97
[30] Targeted therapy for osteosarcoma: a review
Li, Shizhe
Zhang, He
Liu, Jinxin
Shang, Guanning
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, 2023, 149 (09) : 6785 - 6797

← 1 2 3 4 5 →