Synthesis of ribonucleosides of 2-thioxopyrido [2,3-d]pyrimidines by phase transfer catalysis and their antimicrobial activity

被引：6

作者：

Agrawal, H ^{[1
]}

Swati ^{[1
]}

Yadav, AK ^{[1
]}

Prakash, L ^{[1
]}

机构：

[1] Univ Rajasthan, Dept Chem, Jaipur 302004, Rajasthan, India

来源：

PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS | 1998年 / 141卷

关键词：

thioxopyridopyrimidine; ribonucleoside; phase transfer catalysis; spectral studies and antimicrobial-activity;

D O I：

10.1080/10426509808033729

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The ribonucleosides viz; 2-thioxo-3,5,7-trisubstituted-1-(2,3,5-tri-O-benzoyl-beta -D-ribofuranosyl)pyrido[2,3-d]pyrimidine-4 (1H)-ones have been synthesized via phase transfer ribosylation of 2-thioxo- 3,5,7-trisubstituted pyrido[2,3-d]pyrimidine-4(IH)-ones with 2,3,5-tri-O-benzoyl-beta -D- ribofuranosyl bromide in biphasic solvent such as CH2Cl2-50% aqueous NaOH using tetrabutylammonium bromide as phase transfer catalysis (PTC). The synthesized compounds have been characterized by elemental analyses, spectral data and screened for their antimicrobial activity.

引用

页码：159 / 166

页数：8

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