Synthesis of ribonucleosides of 2-thioxopyrido [2,3-d]pyrimidines by phase transfer catalysis and their antimicrobial activity

被引：6
|
作者：
Agrawal, H [1 ]
Swati [1 ]
Yadav, AK [1 ]
Prakash, L [1 ]
机构：
[1] Univ Rajasthan, Dept Chem, Jaipur 302004, Rajasthan, India
来源：
PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS | 1998年 / 141卷
关键词：
thioxopyridopyrimidine; ribonucleoside; phase transfer catalysis; spectral studies and antimicrobial-activity;
D O I：
10.1080/10426509808033729
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
The ribonucleosides viz; 2-thioxo-3,5,7-trisubstituted-1-(2,3,5-tri-O-benzoyl-beta -D-ribofuranosyl)pyrido[2,3-d]pyrimidine-4 (1H)-ones have been synthesized via phase transfer ribosylation of 2-thioxo- 3,5,7-trisubstituted pyrido[2,3-d]pyrimidine-4(IH)-ones with 2,3,5-tri-O-benzoyl-beta -D- ribofuranosyl bromide in biphasic solvent such as CH2Cl2-50% aqueous NaOH using tetrabutylammonium bromide as phase transfer catalysis (PTC). The synthesized compounds have been characterized by elemental analyses, spectral data and screened for their antimicrobial activity.
引用
收藏
页码：159 / 166
页数：8
相关论文
共 50 条
  • [1] Synthesis of some 2-thioxopyrido[2,3-d]pyrimidine ribofuranosides and their antimicrobial activity
    Kumar, N
    Singh, G
    Yadav, AK
    PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS, 2001, 175 : 217 - 225
  • [2] PYRIDO[2,3-D]PYRIMIDINES .2. SYNTHESIS OF RIBONUCLEOSIDES OF 4-OXOPYRIDO[2,3-D]PYRIMIDINES AND 2,4-DIOXO[PYRIDO[2,3-D]PYRIMIDINES
    RIZKALLA, BH
    STOUT, MG
    ROBINS, RK
    BROOM, AD
    JOURNAL OF ORGANIC CHEMISTRY, 1972, 37 (25): : 3975 - 3979
  • [3] [γ-Fe2O3@HAp-SO3H] an efficient nanocatalyst for the synthesis of highly functionalised 2-thioxopyrido[2,3-d]pyrimidines
    Mamaghani, Manouchehr
    Taati, Zahra
    Rasoulian, Mona
    Yousefizad, Javad
    Toraji, Nooshin
    Mohsenimehr, Mona
    Nia, Roghayeh Hossein
    JOURNAL OF CHEMICAL RESEARCH, 2016, (01) : 29 - 34
  • [4] SYNTHESIS OF THIOPYRANO [2,3-D]PYRIMIDINES AND THIENO [2,3-D]PYRIMIDINES
    SANTILLI, AA
    SCOTESE, AC
    JOURNAL OF HETEROCYCLIC CHEMISTRY, 1977, 14 (03) : 361 - 365
  • [5] SYNTHESIS OF THIOPYRANO[2,3-D]PYRIMIDINES AND THIENO[2,3-D]PYRIMIDINES
    ASSY, MG
    ELKAFRAWY, A
    HASSANIEN, MM
    POLISH JOURNAL OF CHEMISTRY, 1995, 69 (06) : 887 - 891
  • [6] SYNTHESIS OF 2-ARYLTHIOPYRANO[2,3-D]PYRIMIDINES AND THIENO[2,3-D]PYRIMIDINES
    ELBAHAIE, S
    ASSY, MG
    JOURNAL OF THE CHINESE CHEMICAL SOCIETY, 1990, 37 (05) : 497 - 500
  • [7] SYNTHESIS OF 2-ARYLTHIOPYRANO[2,3-D]PYRIMIDINES AND THIENO[2,3-D]PYRIMIDINES
    ASSY, MG
    HASSANIEN, MM
    ABDELRAHMAN, S
    PHARMAZIE, 1990, 45 (10): : 792 - 793
  • [8] Pyrido [2,3-d] pyrimidines and their ribofuranosides:: Synthesis and antimicrobial evaluations
    Khatoon, S
    Kumar, N
    Yadav, AK
    INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY, 2004, 13 (04) : 331 - 334
  • [9] Pyrido[2,3-d]pyrimidines and their ribofuranosides:: Synthesis and antimicrobial investigations
    Kumar, Naresh
    Tiwari, Sangeeta
    Yadav, Ashok K.
    INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY, 2007, 46 (04): : 702 - 706
  • [10] PYRROLO[2,3-D]PYRIMIDINES .1. SYNTHESIS OF NOVEL PYRROLO[2,3-D] PYRIMIDINE-DERIVATIVES WITH ANTIMICROBIAL ACTIVITY
    ELBAYOUKI, KAM
    BASYOUNI, WM
    HOSNI, H
    ELDEEN, AS
    JOURNAL OF CHEMICAL RESEARCH-S, 1995, (08): : 314 - 315
12345