Treat to Target in Axial Spondyloarthritis Pros, Cons, and Future Directions

被引：7

作者：

Liew, Jean W. ^{[1
]}

Dubreuil, Maureen ^{[2
]}

机构：

[1] Univ Washington, Dept Med, Div Rheumatol, 1959 Northeast Pacific St,BB561, Seattle, WA 98195 USA

[2] Boston Univ, Sch Med, Sect Rheumatol, 650 Albany St,X201, Boston, MA 02119 USA

来源：

RHEUMATIC DISEASE CLINICS OF NORTH AMERICA | 2020年 / 46卷 / 02期

基金：

美国国家卫生研究院;

关键词：

Treat to target; Disease activity; Axial spondyloarthritis; Ankylosing spondylitis; NONSTEROIDAL ANTIINFLAMMATORY DRUGS; SPINAL RADIOGRAPHIC PROGRESSION; ANKYLOSING-SPONDYLITIS; DISEASE-ACTIVITY; RHEUMATOID-ARTHRITIS; PSORIATIC-ARTHRITIS; PHYSICAL FUNCTION; AMERICAN-COLLEGE; TIGHT CONTROL; MRI INFLAMMATION;

D O I：

10.1016/j.rdc.2020.01.011

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Treat to target describes a management paradigm that involves choosing a clinically relevant target, assessment with validated measures at a prespecified frequency, and a change in therapy if the target is not met. Although guidelines recommend treating to target in axial spondyloarthritis (axSpA), ideal methods to reach this target remain controversial. This review focuses on background for a treat-to-target strategy in axSpA. Potential targets of treatment, association of targets with outcomes, evidence of treatment impact on outcomes, and how treat to target has been incorporated into treatment guidelines are discussed. Treat-to-target trials and the research agenda for studies in axSpA are discussed.

引用

页码：343 / +

页数：15

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