Evaluation of the performance of extreme patient-reported outcomes as surrogate markers for fibromyalgia in axial spondyloarthritis

被引:12
|
作者
Santos-Faria, Daniela [1 ,2 ]
Dougados, Maxime [2 ,3 ]
Gossec, Laure [4 ]
Perrot, Serge [5 ,6 ]
Molto, Anna [3 ]
机构
[1] Hosp Conde Bertiandos, Rheumatol Dept, ULSAM, P-4990078 Ponte do Lima, Portugal
[2] Paris Descartes Univ, Cochin Hosp, AP HP, Rheumatol Dept, Paris, France
[3] Sorbonne Paris Cite, PRES, INSERM, Clin Epidemiol & Biostat,U1153, Paris, France
[4] UPMC Univ, Sorbonne Univ, Pitie Salpetriere Hosp, AP HP,Dept Rheumatol, Paris, France
[5] Paris Descartes Univ, Cochin Hosp, AP HP, Pain Ctr, Paris, France
[6] Paris Descartes Univ, Cochin Hosp, AP HP, INSERM,U987, Paris, France
关键词
Patient-reported outcomes; BASDAI; Fibromyalgia; Spondyloarthritis; ACTIVITY INDEX BASDAI; DISEASE-ACTIVITY; CONCOMITANT FIBROMYALGIA; IMPACT; QUESTIONNAIRE; PREVALENCE;
D O I
10.1007/s00296-018-4200-4
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
ObjectivesThe aim of the study is to evaluate the performance of extreme patient-reported outcomes (PRO) against definitions of fibromyalgia (FM) in patients with axial spondyloarthritis (axSpA).MethodsAncillary analysis of the Predict-SpA trial, an observational study of axSpA patients receiving TNF- inhibitor, was performed. Extreme PRO' was defined as a score8 on three out of the first five Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) questions (scored 0-10). FM was defined by the American College of Rheumatology (ACR) 1990 criteria and the Fibromyalgia Rapid Screening Test (FiRST). Performances of extreme PRO' for FM were evaluated by the sensitivity, specificity and positive likelihood ratio using the 1990 ACR criteria as gold standard. As secondary analysis, the FiRST was used as the external standard.ResultsThe prevalence of extreme PRO' in this population was 28.8% at baseline and decreased to 9.9% at 12 weeks. Extreme PRO' had low sensitivity 12 weeks after TNF initiation (0.18, 95% confidence interval [CI] 0.10-0.27 vs 0.60, 95% CI 0.50-0.71, at baseline), but high specificity (0.92, 95% CI 0.89-0.94 vs 0.78, 95% 0.74-0.82, at baseline), using ACR 1990 criteria as gold standard. Performances when tested against FiRST at 12 weeks showed higher sensitivity (0.27, 95% CI 0.20-0.35) and specificity (0.96, 95% CI 0.94-0.98).ConclusionThe proposed extreme PRO definition showed great specificity for FM recognition in patients with axSpA, suggesting it could be used in observational studies when specific items for FM classification are not available.
引用
收藏
页码:141 / 146
页数:6
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