DSC, X-ray and FTIR studies of a gemfibrozil/dimethyl-β-cyclodextrin inclusion complex produced by co-grinding

被引：63
|
作者：
Aigner, Z. [1 ]
Berkesi, O. [2 ]
Farkas, G. [1 ]
Szabo-Revesz, P. [1 ]
机构：
[1] Univ Szeged, Fac Pharm, Dept Pharmaceut Technol, H-6720 Szeged, Hungary
[2] Univ Szeged, Fac Sci & Informat, Dept Phys Chem & Mat Sci, H-6720 Szeged, Hungary
来源：
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | 2012年 / 57卷
关键词：
Gemfibrozil; Dimethyl-beta-cyclodextrin; DSC; XRPD; FTIR with curve-fitting analysis;
D O I：
10.1016/j.jpba.2011.08.034
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
The steps of formation of an inclusion complex produced by the co-grinding of gemfibrozil and dimethyl-beta-cyclodextrin were investigated by differential scanning calorimetry (DSC), X-ray powder diffractometry (XRPD) and Fourier transform infrared (FTIR) spectroscopy with curve-fitting analysis. The endothermic peak at 59.25 degrees C reflecting the melting of gemfibrozil progressively disappeared from the DSC curves of the products on increase of the duration of co-grinding. The crystallinity of the samples too gradually decreased, and after 35 min of co-grinding the product was totally amorphous. Up to this co-grinding time. XRPD and FTIR investigations indicated a linear correlation between the cyclodextrin complexation and the co-grinding time. After co-grinding for 30 min, the ratio of complex formation did not increase. These studies demonstrated that co-grinding is a suitable method for the complexation of gemfibrozil with dimethyl-beta-cyclodextrin. XRPD analysis revealed the amorphous state of the gemfibrozil-dimethyl-beta-cyclodextrin product. FTIR spectroscopy with curve-fitting analysis may be useful as a semiquantitative analytical method for discriminating the molecular and amorphous states of gemfibrozil. (C) 2011 Elsevier B.V. All rights reserved.
引用
收藏
页码：62 / 67
页数：6
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