A Reproducible In-vivo Model of Lymphatic Malformation in Rats

被引：7

作者：

Sun, Y. ^{[3
,4
,5
,6
]}

Jia, J. ^{[1
,2
]}

Zhang, W. ^{[1
,2
]}

Liu, B. ^{[1
,2
]}

Zhang, Z. ^{[3
,4
,5
,6
]}

Zhao, Y. ^{[1
,2
]}

机构：

[1] Wuhan Univ, Sch Stomatol, Dept Oral & Maxillofacial Surg, Wuhan 430072, Hubei, Peoples R China

[2] Wuhan Univ, Hosp Stomatol, Dept Oral & Maxillofacial Surg, Wuhan 430072, Hubei, Peoples R China

[3] Wuhan Univ, Sch Stomatol, State Key Lab Breeding Base Basic Sci Stomatol, Minist Educ, Wuhan 430072, Hubei, Peoples R China

[4] Wuhan Univ, Hosp Stomatol, State Key Lab Breeding Base Basic Sci Stomatol, Minist Educ, Wuhan 430072, Hubei, Peoples R China

[5] Wuhan Univ, Hosp Stomatol, Key Lab Oral Biomed, Minist Educ, Wuhan 430072, Hubei, Peoples R China

[6] Wuhan Univ, Sch Stomatol, Key Lab Oral Biomed, Minist Educ, Wuhan 430072, Hubei, Peoples R China

来源：

JOURNAL OF COMPARATIVE PATHOLOGY | 2011年 / 145卷 / 04期

关键词：

adjuvant; lymphatic malformation; rat; VEGF-C; ENDOTHELIAL-CELLS; SAFETY; LYMPHANGIOMA; ANTIBODIES; ADJUVANTS; CHILDREN; INFANTS; D2-40; SKIN;

D O I：

10.1016/j.jcpa.2011.02.002

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

The aim of this study was to develop a reproducible rat model of lymphatic malformation. Different types of adjuvant, with and without vascular endothelial growth factor (VEGF)-C, was injected into the neck and floor of the mouth of rats. The rats were killed 2 months after the injection. Injected rats developed cystic lesions in the neck and floor of the mouth. Immunohistochemical examination revealed that the cysts were lined by endothelium; which expressed the lymphatic endothelial markers LYVE-1 and VEGF receptor-3. Raman spectra of the liquid contents of the cysts were similar in all injected rats. Transmission electron microscopy revealed that the endothelial cells had no basement membrane or surrounding pericytes. The cystic lesions were consistent with human lymphatic malformation. This animal model could be used to investigate pathogenesis of lymphatic malformation and its responses to candidate therapies. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：390 / 398

页数：9

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