Pertussis toxin increases isoproterenol induced relaxation in field-stimulated ileum

被引：7

作者：

Sawyer, G ^{[1
]}

Ehlert, F ^{[1
]}

机构：

[1] Univ Calif Irvine, Coll Med, Dept Pharmacol, Irvine, CA 92697 USA

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1999年 / 367卷 / 01期

关键词：

acetylcholine release; pertussis toxin; muscarinic receptor; ileum; field-stimulated; muscarinic M-2 receptor;

D O I：

10.1016/S0014-2999(99)00002-3

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

We investigated the effects of pertussis toxin on contraction in field-stimulated guinea pig ileum in the absence and presence of isoproterenol. Field-stimulation elicited pertussis toxin-insensitive contractions. Cumulative addition of isoproterenol produced a maximal 52% reduction in the contractile response. Following pertussis toxin-treatment, the maximal inhibitory effect of isoproterenol increased to 83%. Pertussis toxin had no effect on the ability isoproterenol to inhibit contractions elicited by histamine agonists. Our results suggest that the increased effectiveness of isoproterenol in pertussis toxin-treated ileum is due to an uncoupling of the muscarinic M-2 receptor contractile mechanism. (C) 1999 Elsevier Science B.V. All rights reserved.

引用

页码：81 / 84

页数：4

共 37 条

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BJU INTERNATIONAL, 2001, 87 (01) : 98 - 103
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BJU INTERNATIONAL, 2001, 88 (03) : 303 - 304
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BJU INTERNATIONAL, 2001, 88 (03) : 304 - 304
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