CacyBP/SIP Protein Promotes Proliferation and G1/S Transition of Human Pancreatic Cancer Cells

被引：26
|
作者：
Chen, Xiong [1 ,2 ]
Mo, Ping [1 ,2 ]
Li, Xiaohua [1 ,2 ]
Zheng, Peichan [3 ]
Zhao, Lina [1 ,2 ]
Xue, Zengfu [1 ,2 ]
Ren, Gui [1 ,2 ]
Han, Guohong [1 ,2 ]
Wang, Xin [1 ,2 ]
Fan, Daiming [1 ,2 ]
机构：
[1] Fourth Mil Med Univ, State Key Lab Canc Biol, Xian 710032, Shaanxi, Peoples R China
[2] Fourth Mil Med Univ, Xijing Hosp Digest Dis, Xian 710032, Shaanxi, Peoples R China
[3] Peoples Hosp Fujian Prov, Dept Clin Lab, Fuzhou, Fujian, Peoples R China
来源：
MOLECULAR CARCINOGENESIS | 2011年 / 50卷 / 10期
基金：
中国国家自然科学基金;
关键词：
CacyBP/SIP; proliferation; cell cycle; pancreatic cancer; BINDING-PROTEIN; SIGNALING PATHWAY; CALCYCLIN; EXPRESSION; PROSTATE; APOPTOSIS; RECEPTOR; DIFFERENTIATION; TARGET; GROWTH;
D O I：
10.1002/mc.20737
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Calcyclin-binding protein or Siah-1-interacting protein (CacyBP/SIP), a component of the ubiquitin-mediated proteolysis, could participate in beta-catenin degradation, which was found to be related to the malignant phenotypes of pancreatic cancer previously. However, the role of CacyBP/SIP itself in pancreatic cancer has not been investigated. In the present study, CacyBP/SIP expression was assayed and manipulated to reveal the potential mechanism in pancreatic cancer carcinogenesis. Here, we show that CacyBP/SIP is over-expressed in pancreatic cancer cells. Down-regulation of CacyBP/SIP by small interference RNA (siRNA) severely suppresses the proliferation and tumorigenesis in pancreatic cancer. G1/S transition arrest induced by inhibition of CacyBP/SIP is at least partly mediated by down-regulation of Cyclin E and CDK2 as well as up-regulation of p27 and Rb. Collectively, CacyBP/SIP as an enhancer of pancreatic cancer malignance might develop into another possible therapeutic target. (C) 2011 Wiley-Liss, Inc.
引用
收藏
页码：804 / 811
页数：8
相关论文
共 50 条
  • [31] Upregulation of E2F8 promotes cell proliferation and tumorigenicity in breast cancer by modulating G1/S phase transition
    Ye, Liping
    Guo, Ling
    He, Zhenyu
    Wang, Xi
    Lin, Chuyong
    Zhang, Xin
    Wu, Shu
    Bao, Yong
    Yang, Qi
    Song, Libing
    Lin, Huanxin
    ONCOTARGET, 2016, 7 (17) : 23757 - 23771
  • [32] PSD3 is an oncogene that promotes proliferation, migration, invasion, and G1/S transition while inhibits apoptotic in papillary thyroid cancer
    Jin, Lingli
    Zheng, Danni
    Bhandari, Adheesh
    Chen, Danxiang
    Xia, Erjie
    Guan, Yaoyao
    Wen, Jialiang
    Wang, Ouchen
    JOURNAL OF CANCER, 2021, 12 (18): : 5413 - 5422
  • [33] The regulatory network for the G1/S transition in Saccharomyces cerevisiae promotes the understanding of cancer developmental mechanisms
    Zhou, Cheng
    Li, Pan
    Qu, Yuwei
    Zuo, Jiahe
    Hao, Zhimin
    Liu, Tongtong
    BIOTECHNOLOGY & BIOTECHNOLOGICAL EQUIPMENT, 2024, 38 (01)
  • [34] Roles of PKC isozymes in G1◊ S phase transition in human ductal pancreatic cancers.
    Kopras, UJ
    Cornelius, JR
    Babcock, GF
    Ulrich, CD
    GASTROENTEROLOGY, 2001, 120 (05) : A722 - A723
  • [35] Gankyrin promotes the proliferation of human pancreatic cancer
    Meng, Yun
    He, Lijie
    Guo, Xuegang
    Tang, Shanhong
    Zhao, Xiaodi
    Du, Rui
    Jin, Jiang
    Bi, Qian
    Li, Hao
    Nie, Yongzhan
    Liu, Jie
    Fan, Daiming
    CANCER LETTERS, 2010, 297 (01) : 9 - 17
  • [36] PLEKHA4 Promotes Wnt/β-catenincatenin Signaling-Mediated G1/S Transition and Proliferation in Melanoma
    Shah, Adnan Shami
    Cao, Xiaofu
    White, Andrew
    Baskin, Jeremy
    FASEB JOURNAL, 2021, 35
  • [37] Albumin promotes proliferation of G1 arrested serum starved hepatocellular carcinoma cells
    Ibrahim, Badr
    Stange, Jan
    Dominik, Adrian
    Sauer, Martin
    Doss, Sandra
    Eggert, Martin
    PEERJ, 2020, 8
  • [38] S100A6 Protein Negatively Regulates CacyBP/SIP-Mediated Inhibition of Gastric Cancer Cell Proliferation and Tumorigenesis
    Ning, Xiaoxuan
    Sun, Shiren
    Zhang, Kun
    Liang, Jie
    Chuai, Yucai
    Li, Yuan
    Wang, Xiaoming
    PLOS ONE, 2012, 7 (01):
  • [39] CONTROL OF THE G1/S TRANSITION
    REED, SI
    BAILLY, E
    DULIC, V
    HENGST, L
    RESNITZKY, D
    SATO, K
    SLINGERLAND, J
    WON, KA
    JOURNAL OF CELLULAR BIOCHEMISTRY, 1995, : 6 - 6
  • [40] The effect of S100A6 on nuclear translocation of CacyBP/SIP in colon cancer cells
    Feng, Shanshan
    Zhou, Qiaozhi
    Yang, Bo
    Li, Qianqian
    Liu, Aiqin
    Zhao, Yingying
    Qiu, Changqing
    Ge, Jun
    Zhai, Huihong
    PLOS ONE, 2018, 13 (03):
12345