Is cellular senescence important in pediatric kidney disease?

被引：5

作者：

Jacobi, Christoph ^{[1
]}

Hoemme, Meike ^{[1
]}

Melk, Anette ^{[1
]}

机构：

[1] Childrens Hosp, Hannover Med Sch, Dept Pediat Nephrol Gastroenterol & Metab Dis, D-30625 Hannover, Germany

来源：

PEDIATRIC NEPHROLOGY | 2011年 / 26卷 / 12期

关键词：

Somatic cellular senescence; Telomere shortening; p16(INK4a); Renal senescence; Allograft nephropathy; CYCLE INHIBITOR P16(INK4A); TELOMERE LENGTH; PREMATURE SENESCENCE; TUMOR SUPPRESSION; UP-REGULATION; REPLICATIVE SENESCENCE; INTERSTITIAL FIBROSIS; INCREASED EXPRESSION; CALORIC RESTRICTION; ENDOTHELIAL-CELLS;

D O I：

10.1007/s00467-010-1740-6

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Somatic cellular senescence (SCS) describes the limited ability of cells to divide. Normally, SCS is associated with physiological aging, but evidence suggests that it may play a role in disease progression, even in young patients. Stressors such as acute injury or chronic inflammation may induce SCS, which in turn exhausts organ regenerative potential. This review summarizes what is known about SCS in the kidney with aging and disease. As most patients with chronic kidney disease (CKD) also develop cardiovascular complications, a second focus of this review deals with the role of SCS in cardiovascular disease. Also, as SCS seems to accelerate CKD and cardiovascular disease progression, developing strategies for new treatment options that overcome SCS or protect a patient from it represents an exciting challenge.

引用

页码：2121 / 2131

页数：11

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