Experimental Evaluation and Modeling of Adsorption Phenomena of Nanoliposomes on Poly(dimethylsiloxane) Surfaces

Nanoparticles, such as exosomes or liposomes, have been widely studied using poly(dimethylsiloxane) (PDMS) microchannels. The interaction between nanoparticles and solid surfaces is an important subject for basic and applied research on nanoparticles, but there have been few reports on the use of microchannels for this purpose. Micro-scale systems serve as a useful platform for adsorption analysis because of their large surface-to-volume ratio. In this study, we attempted to develop a platform to study the adsorption phenomena of nanoparticles on solid surfaces using a microchannel, in which a model that analyzes dynamic (i.e., non-equilibrium) adsorption was used. This model allowed quantitative analysis of nanoliposome adsorption onto the surface of a PDMS microchannel.