Dietary Anthocyanins and Insulin Resistance: When Food Becomes a Medicine

被引:106
|
作者
Belwal, Tarun [1 ]
Nabavi, Seyed Fazel [2 ]
Nabavi, Seyed Mohammad [2 ]
Habtemariam, Solomon [3 ,4 ]
机构
[1] GB Pant Inst Himalayan Environm & Dev, Almora 263643, Uttarakhand, India
[2] Baqiyatallah Univ Med Sci, Appl Biotechnol Res Ctr, POB 19395-5487, Tehran, Iran
[3] Univ Greenwich, Pharmacognosy Res Labs, Cent Ave, Chatham ME4 4TB, Kent, England
[4] Univ Greenwich, Herbal Anal Serv UK, Cent Ave, Chatham ME4 4TB, Kent, England
来源
NUTRIENTS | 2017年 / 9卷 / 10期
关键词
dietary anthocyanins; insulin resistance; diabetes; obesity; INDUCED DIABETIC-RATS; ACTIVATED PROTEIN-KINASE; ANTI-ALPHA-GLUCOSIDASE; NECROSIS-FACTOR-ALPHA; HIGH-FAT DIET; BLACK SOYBEAN ANTHOCYANINS; FICUS-BENGALENSIS LINN; PELTATUM TORR. ENGL; E-DEFICIENT MICE; IN-VITRO MODELS;
D O I
10.3390/nu9101111
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Insulin resistance is an abnormal physiological state that occurs when insulin from pancreatic beta-cells is unable to trigger a signal transduction pathway in target organs such as the liver, muscles and adipose tissues. The loss of insulin sensitivity is generally associated with persistent hyperglycemia (diabetes), hyperinsulinemia, fatty acids and/or lipid dysregulation which are often prevalent under obesity conditions. Hence, insulin sensitizers are one class of drugs currently employed to treat diabetes and associated metabolic disorders. A number of natural products that act through multiple mechanisms have also been identified to enhance insulin sensitivity in target organs. One group of such compounds that gained interest in recent years are the dietary anthocyanins. Data from their in vitro, in vivo and clinical studies are scrutinized in this communication to show their potential health benefit through ameliorating insulin resistance. Specific mechanism of action ranging from targeting specific signal transduction receptors/enzymes to the general antioxidant and anti-inflammatory mechanisms of insulin resistance are presented.
引用
收藏
页数:22
相关论文
共 50 条
  • [21] When the Aberrant Becomes the Accepted: The Rise of Hallway Care in Emergency Medicine
    Feldman, James A.
    ACADEMIC EMERGENCY MEDICINE, 2020, 27 (03) : 256 - 258
  • [22] WHEN LOOTING BECOMES A RIGHT - URBAN POVERTY AND FOOD RIOTS IN ARGENTINA
    SERULNIKOV, S
    LATIN AMERICAN PERSPECTIVES, 1994, 21 (03) : 69 - 89
  • [23] Food and governance practices in schools: when health becomes a corporate issue
    Piquinela, Pablo
    CADERNOS DE SAUDE PUBLICA, 2024, 40 (04):
  • [25] When food becomes a drug: Nonanabolic nutritional supplement use in athletes
    Schwenk, TL
    Costley, CD
    AMERICAN JOURNAL OF SPORTS MEDICINE, 2002, 30 (06): : 907 - 916
  • [26] Dietary fats, obesity and insulin resistance
    Storlien, LH
    Else, PL
    Edwell, FC
    Thomas, TC
    Tapsell, LC
    Calvert, GD
    Higgins, JA
    PROGRESS IN OBESITY RESEARCH: 8, 1999, : 495 - 501
  • [27] DIETARY FACTORS IN OBESITY AND INSULIN RESISTANCE
    LOVEJOY, J
    DIGIROLAMO, M
    FASEB JOURNAL, 1991, 5 (05): : A1316 - A1316
  • [28] Dietary fatty acids and insulin resistance
    Lovejoy J.C.
    Current Atherosclerosis Reports, 1999, 1 (3) : 215 - 220
  • [29] Type of dietary fat and insulin resistance
    Rivellese, AA
    De Natale, C
    Lilli, S
    LIPIDS AND INSULIN RESISTANCE: THE ROLE OF FATTY ACID METABOLISM AND FUEL PARTITIONING, 2002, 967 : 329 - 335
  • [30] WHEN TO REFER - PROBLEMS OF INSULIN RESISTANCE
    MOLLER, DE
    FLIER, JS
    HOSPITAL PRACTICE, 1988, 23 (10A): : 83 - &