Erythroid Differentiation Regulator 1 Strengthens TCR Signaling by Enhancing PLCγ1 Signal Transduction Pathway

被引：0
|
作者：
Kim, Myun Soo [1 ]
Park, Dongmin [1 ]
Lee, Sora [1 ]
Park, Sunyoung [1 ]
Kim, Kyung Eun [2 ]
Kim, Tae Sung [3 ]
Park, Hyun Jeong [1 ]
Cho, Daeho [1 ,4 ]
机构：
[1] Kine Sci, 525 Seolleung Ro, Seoul 06149, South Korea
[2] Sookmyung Womens Univ, Dept Cosmet Sci, Cheongpa Ro 47,Gil 100,Cheongpa Dong 2ga, Seoul 04310, South Korea
[3] Korea Univ, Coll Life Sci & Biotechnol, Div Life Sci, 5 Ga, Seoul 02841, South Korea
[4] Korea Univ, Inst Convergence Sci, Anam Ro 145, Seoul 02841, South Korea
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2022年 / 23卷 / 02期
关键词：
Erdr1; TCR signal modulation; PLC gamma 1; T-CELL-ACTIVATION; NFAT; TRANSCRIPTION; PLAYS;
D O I：
10.3390/ijms23020844
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Erythroid differentiation regulator 1 (Erdr1) has previously been reported to control thymocyte selection via TCR signal regulation, but the effect of Erdr1 as a TCR signaling modulator was not studied in peripheral T cells. In this report, it was determined whether Erdr1 affected TCR signaling strength in CD4 T cells. Results revealed that Erdr1 significantly enhanced the anti-TCR antibody-mediated activation and proliferation of T cells while failing to activate T cells in the absence of TCR stimulation. In addition, Erdr1 amplified Ca2+ influx and the phosphorylation of PLC gamma 1 in CD4 T cells with the TCR stimuli. Furthermore, NFAT1 translocation into nuclei in CD4 T cells was also significantly promoted by Erdr1 in the presence of TCR stimulation. Taken together, our results indicate that Erdr1 positively modulates TCR signaling strength via enhancing the PLC gamma 1/Ca2+/NFAT1 signal transduction pathway.
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页数：9
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