A mapping platform for mitotic crossover by single-cell multi-omics

被引：1

作者：

Chovanec, Peter ^{[1
]}

Yin, Yi ^{[1
]}

机构：

[1] Univ Calif Los Angeles, Dept Human Genet, Los Angeles, CA 90095 USA

来源：

DNA REPLICATION-REPAIR INTERFACE | 2021年 / 661卷

基金：

美国国家卫生研究院;

关键词：

GENOME-WIDE; MUTATIONAL SIGNATURES; STRAND BREAKS; END RESECTION; INSTABILITY; REPAIR; RECOMBINATION;

D O I：

10.1016/bs.mie.2021.08.017

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Mitotic crossovers have the potential to cause large-scale genome rearrangements. Here, we describe high-throughput, single-cell, whole-genome sequencing methods for mapping crossovers genome-wide at scale. The methods are generalizable to various eukaryotes and to other end points requiring high-throughput, high-coverage single cell sequencing.

引用

页码：183 / 204

页数：22

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