Antibacterial activity of copper-containing clinoptilolite/PVC composites toward clinical isolate of Acinetobacter baumannii

被引:5
|
作者
Milenkovic, Jelena K. [1 ]
Hrenovic, Jasna J. [2 ]
Goic-Barisic, Ivana S. [3 ,4 ]
Tomic, Milos D. [1 ]
Rajic, Nevenka Z. [5 ]
机构
[1] Univ Belgrade, Fac Technol & Met, Innovat Ctr, Belgrade 11000, Serbia
[2] Univ Zagreb, Fac Sci, Div Biol, Zagreb 10000, Croatia
[3] Split Univ Hosp, Split 21000, Croatia
[4] Univ Split, Dept Clin Microbiol, Sch Med, Split 21000, Croatia
[5] Univ Belgrade, Fac Technol & Met, Belgrade 11000, Serbia
关键词
natural zeolite; multidrug resistance; polymers; poly(vinyl chloride); amino acids; D-AMINO ACIDS; BIOFILM FORMATION; NATURAL CLINOPTILOLITE; ANTIMICROBIAL ACTIVITY; PVC COMPOSITE; ZEOLITE; SURFACES;
D O I
10.2298/JSC141225017M
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
The multidrug-resistant bacteria Acinetobacter baumannii cause serious hospital infections. Commercial poly(vinyl chloride) (PVC) used for endotracheal tubes was modified in order to obtain a composite with an antibacterial effect towards a clinical isolate of A. baumannii ST145. The composites were prepared by addition of different amounts of copper-containing zeolite tuff (CuZ) and by successive impregnation with D-tyrosine (D-Tyr) solution. The composites that were obtained by addition of CuZ (CuZ PVC) only did not exhibit an antibacterial effect. The impregnation of the CuZ PVC by D-Tyr resulted in an antibacterial effect which was explained by a synergistic effect of CuZ and D-Tyr. Rheological tests confirmed that the modification of PVC by CuZ does not affect its processability and reformability.
引用
收藏
页码:819 / 826
页数:8
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