Synthesis and Cytotoxicity of 6-Substituted 1,4-Naphthoquinone Oxime Derivatives (II)

被引：6
|
作者：
Huang, G. [1 ]
Zhao, H. R. [2 ]
Li, S. S. [1 ]
机构：
[1] Shanghai Jiao Tong Univ, Sch Pharm, Shanghai 200240, Peoples R China
[2] Dali Univ, Sch Pharmaceut Sci & Chem, Dali 671000, Peoples R China
来源：
RUSSIAN JOURNAL OF GENERAL CHEMISTRY | 2017年 / 87卷 / 12期
基金：
美国国家科学基金会;
关键词：
1,4-naphthoquinone; oxime derivatives; synthesis; cytotoxic activity; ANTITUMOR-ACTIVITY; AGENTS; ANTIFUNGAL; DESIGN;
D O I：
10.1134/S1070363217120416
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
In the present study, a series of 1,4-naphthoquinone oxime derivatives has been synthesized. The structures were confirmed by spectroscopic methods. The newly synthesized compounds were evaluated for their in vitro cytotoxicity. Among those, the compounds 8c, 8d, 8e, 12a, and 12b demonstrated potent cytotoxic activity comparable with that of the reference drug 5-Fu.
引用
收藏
页码：2979 / 2985
页数：7
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