Altered intrinsic connectivity distribution in internet gaming disorder and its associations with psychotherapy treatment outcomes

被引:22
|
作者
Liu, Lu [1 ,2 ,3 ,4 ,20 ]
Potenza, Marc N. [5 ,6 ,7 ,8 ,9 ]
Lacadie, Cheryl M. [10 ]
Zhang, Jin-Tao [3 ,4 ,11 ]
Yip, Sarah W. [5 ,6 ]
Xia, Cui-Cui [2 ]
Lan, Jing [2 ,12 ]
Yao, Yuan-Wei [13 ,14 ,15 ,16 ,17 ,18 ]
Deng, Lin-Yuan [19 ]
Park, Soyoung Q. [1 ,14 ,15 ,16 ,17 ,20 ,21 ]
Fang, Xiao-Yi [2 ]
机构
[1] German Inst Human Nutr Potsdam Rehbrucke, Dept Decis Neurosci & Nutr, Nuthetal, Germany
[2] Beijing Normal Univ, Fac Psychol, Inst Dev Psychol, Beijing 100875, Peoples R China
[3] Beijing Normal Univ, State Key Lab Cognit Neurosci & Learning, Beijing 100875, Peoples R China
[4] Beijing Normal Univ, IDG McGovern Inst Brain Res, Beijing 100875, Peoples R China
[5] Yale Sch Med, Dept Psychiat, New Haven, CT USA
[6] Yale Sch Med, Child Study Ctr, New Haven, CT USA
[7] Yale Univ, Dept Neurosci, New Haven, CT USA
[8] Connecticut Mental Hlth Ctr, New Haven, CT USA
[9] Connecticut Council Problem Gambling, Wethersfield, CT USA
[10] Yale Sch Med, Dept Radiol & Biomed Imaging, New Haven, CT USA
[11] Beijing Normal Univ, Ctr Collaborat & Innovat Brain & Learning Sci, Beijing, Peoples R China
[12] Northwestern Univ, Family Inst, Evanston, IL USA
[13] Free Univ Berlin, Dept Educ & Psychol, Berlin, Germany
[14] Charite Univ Med Berlin, Einstein Ctr Neurosci Berlin, Berlin, Germany
[15] Free Univ Berlin, Berlin, Germany
[16] Humboldt Univ, Berlin, Germany
[17] Berlin Inst Hlth, Berlin, Germany
[18] Humboldt Univ, Berlin Sch Mind & Brain, Berlin, Germany
[19] Beijing Normal Univ, Fac Educ, Beijing, Peoples R China
[20] Deutsch Zentrum Diabet DZD, Neuherberg, Germany
[21] Charite Univ Med Berlin, Neurosci Res Ctr, Berlin, Germany
基金
中国国家自然科学基金;
关键词
craving behavioral intervention; internet gaming disorder; intrinsic connectivity distribution; resting-state fMRI; FUNCTIONAL CONNECTIVITY; CUE REACTIVITY; DEFAULT-MODE; FMRI; ABSTINENCE; DEPENDENCE; ADDICTION; INVENTORY; COGNITION; NETWORKS;
D O I
10.1111/adb.12917
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Alterations in brain connectivity have been implicated in internet gaming disorder (IGD). However, little is known about alterations in whole-brain connectivity and their associations with long-term treatment outcomes. Here, we used a relatively new analytic approach, intrinsic connectivity distribution (ICD) analysis, to examine brain connectivity in 74 IGD participants and 41 matched healthy controls (HCs) and conducted post hoc seed-based resting-state functional connectivity (rsFC) analyses based on the ICD findings. We also examined how these findings related to outcomes involving a craving behavioral intervention (CBI) for IGD. IGD participants showed less whole-brain connectivity in the left angular gyrus and ventromedial prefrontal cortex (vmPFC) compared with HC participants. Seed-based rsFC analyses revealed that the left angular gyrus in the IGD group showed less connectivity with areas involved in the default-mode network and greater connectivity with areas in the salience and executive control networks. CBI was associated with improved connectivity within regions in the default-mode network and regions across the default-mode and salience networks. ICD-identified connectivity differences in the left angular gyrus and vmPFC were related to changes in craving and severity of addiction 6 months after the intervention. The findings suggest that IGD is associated with alterations in brain connectivity that may be sensitive to interventions. Thus, the findings have implications for understanding mechanisms underlying CBI effects and for further treatment development.
引用
收藏
页数:12
相关论文
共 50 条
  • [41] Differences in functional connectivity between alcohol dependence and internet gaming disorder
    Han, Ji Won
    Han, Doug Hyun
    Bolo, Nicolas
    Kim, BoAh
    Kim, Boong Nyun
    Renshaw, Perry F.
    ADDICTIVE BEHAVIORS, 2015, 41 : 12 - 19
  • [42] The Associations Between Gaming Motivation and Internet Gaming Disorder: Systematic Review and Meta-analysis
    Wang, Hsin-Yi
    Cheng, Cecilia
    JMIR MENTAL HEALTH, 2022, 9 (02):
  • [43] Typology of Internet gaming disorder and its clinical implications
    Lee, Seung-Yup
    Lee, Hae Kook
    Choo, Hyekyung
    PSYCHIATRY AND CLINICAL NEUROSCIENCES, 2017, 71 (07) : 479 - 491
  • [44] INTERNET GAMING DISORDER (IGD): ASSOCIATIONS WITH CHANGES IN GRAY MATTER AND BEHAVIORS
    Nikroo, K.
    Cheng, N.
    Huang, J.
    Lim, S.
    Raghavan, R.
    Rajpara, S.
    Afghani, B.
    JOURNAL OF INVESTIGATIVE MEDICINE, 2019, 67 (01) : 216 - 217
  • [45] Assessment of Hazardous Gaming in children and its dissimilarities and overlaps with Internet Gaming Disorder
    Kewitz, Sonja
    Leo, Katharina
    Rehbein, Florian
    Lindenberg, Katajun
    FRONTIERS IN PSYCHIATRY, 2023, 14
  • [46] The Psychotherapy of Internet Addiction with special consideration of Gaming Disorder and Online Sex Addiction
    Woelfling, Klaus
    JOURNAL OF BEHAVIORAL ADDICTIONS, 2022, 11 : 1 - 1
  • [47] Altered Cerebellar Functional Connectivity with Intrinsic Connectivity Networks in Adults with Major Depressive Disorder
    Liu, Li
    Zeng, Ling-Li
    Li, Yaming
    Ma, Qiongmin
    Li, Baojuan
    Shen, Hui
    Hu, Dewen
    PLOS ONE, 2012, 7 (06):
  • [48] DEVELOPMENT OF STEP FOR THE ASSESSMENTAND TREATMENT OF THE INTERNET GAMING DISORDER
    Lee, H. K.
    Choi, S. W.
    Hwang, S. H.
    ALCOHOL AND ALCOHOLISM, 2014, 49
  • [49] Internet Gaming Disorder: Theory, Assessment, Treatment, and Prevention
    Price, Jessica
    EDUCATIONAL AND DEVELOPMENTAL PSYCHOLOGIST, 2019, 36 (02): : 90 - 90
  • [50] INTERNET GAMING DISORDER AND PROBLEMATIC INTERNET USE: EMERGING TREATMENT APPROACHES
    Tam, P.
    AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY, 2016, 50 : 96 - 96