Small Molecule Inhibitor of ITK Disrupts TCR Signaling and Demonstrates Anti-Tumor Efficacy

被引:0
|
作者
Faris, Mary [1 ]
Malyankar, Uriel M. [1 ]
Zeng, Qingping [1 ]
Flynn, Gary A. [2 ]
Fuer, Gerold [3 ]
Kertesz, Nathalie L. [1 ]
Vuga, Danka [1 ]
Lee, Sandra [4 ]
Rosario, Darlene [1 ]
Bot, Adrian [1 ]
机构
[1] MannKind Corp, Valencia, CA USA
[2] Spacefill Enterprises LLC, Oro Valley, AZ USA
[3] SUNY Upstate Med Univ, Syracuse, NY USA
[4] Biogen Idec Inc, San Diego, CA USA
关键词
D O I
暂无
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
引用
收藏
页码:1603 / 1604
页数:2
相关论文
共 50 条
  • [21] Inhibition of Weel kinase by small molecule inhibitor enhances anti-tumor efficacy of DNA damaging agents specifically in p53-negative cancers
    Hirai, Hiroshi
    Iwasawa, Yoshikazu
    Okada, Megumu
    Arai, Tsuyoshi
    Nishibata, Toshihide
    Kobayashi, Makiko
    Kimura, Toshifumi
    Kaneko, Naoki
    Ohtani, Junko
    Sakai, Takumi
    Mizuarai, Shinji
    Yoshizumi, Takashi
    Kotani, Hidehito
    CANCER RESEARCH, 2009, 69
  • [22] Rogaratinib, a small molecule pan-FGFR inhibitor potently inhibits FGFR4-phosphorylation and exerts anti-tumor efficacy in vivo and in vitro
    Politz, Oliver
    Gruenewald, Sylvia
    Walter, Alexander
    Siegel, Franziska
    Scholz, Arne
    Bender, Sebastian
    Kneip, Christoph
    Ellinghaus, Peter
    CANCER RESEARCH, 2018, 78 (13)
  • [23] Effects of antibiotics on the anti-tumor efficacy of immune checkpoint inhibitor therapy
    Nie, Fangfang
    Guo, Jungang
    Pan, Jiayi
    Guo, Zhaojiao
    Wang, Chun
    Yan, Jun
    Ma, Weina
    CLINICAL & TRANSLATIONAL ONCOLOGY, 2025, 27 (02): : 790 - 799
  • [24] MLN8054, an Aurora A Kinase inhibitor, demonstrates potent anti-tumor activity in disseminated tumor models
    Zhang, M.
    Meetze, M.
    Huck, J.
    Silva, M.
    Sells, T.
    Claiborne, C.
    Manfredi, M.
    EJC SUPPLEMENTS, 2006, 4 (12): : 113 - 113
  • [25] An oral and selective CDK12 inhibitor demonstrates robust anti-tumor activity.
    Hu, Shanhu
    Moebius, David
    Dworakowski, Wojciech
    Cooper, Elliott
    LaPlaca, Derek
    Alnemy, Sydney
    Perera, Phone
    Marineau, Jason
    Chuaqui, Claudio
    Carulli, John P.
    Olson, Eric
    CANCER RESEARCH, 2022, 82 (12)
  • [26] Anti-tumor Activity of the Small Molecule Inhibitor PRI-724 Against β-Catenin-activated Hepatocellular Carcinoma
    Gabata, Ryosuke
    Harada, Kenichi
    Mizutani, Yuki
    Ouchi, Hirofumi
    Yoshimura, Kaori
    Sato, Yasunori
    Kitao, Azusa
    Kimura, Kiminori
    Kouji, Hiroyuki
    Miyashita, Tomoharu
    Tajima, Hidehiro
    Ohta, Tetsuo
    ANTICANCER RESEARCH, 2020, 40 (09) : 5211 - 5219
  • [27] CB-708, an orally bioavailable small molecule inhibitor of CD73 with immunostimulatory and anti-tumor activity
    Lee, Clarissa
    Bhupathi, Deepthi
    Billedeau, Roland
    Chen, Jason
    Chen, Lijing
    Dang, Rosalyn
    Gross, Matthew
    Huang, Tony
    Li, Weiqun
    Ma, Yong
    MacKinnon, Andrew
    Marguier, Gisele
    Neou, Silinda
    Parlati, Francesco
    Sotirovska, Natalija
    Spurlock, Sandra
    Stanton, Timothy
    Steggerda, Susanne
    Zhang, Jing
    Zhang, Winter
    Li, Jim
    JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2019, 7
  • [28] NOVEL SMALL MOLECULE HPK1 INHIBITOR PCC-1 INDUCES STRONG ANTI-TUMOR ACTIVITY
    Das, Sanjib
    Mandadi, Sravan
    Saini, Jagmohan
    Chaudhari, Sachin
    Deshpande, Ameya
    Chinnapattu, Murugan
    Bajpai, Malini
    Pangre, Priyanka
    Potdar, Varada
    Marathe, Megha
    Sawant, Pooja
    Akarte, Atul
    Misra, Chandrasekhar
    Das, Subhadip
    Singh, Anuj
    Das, Avratanu
    Lambade, Pandurang
    Tirumalasetty, Chaitanya
    Patole, Raju
    Biswas, Nilanjana
    Karande, Vikas
    Shah, Heta
    Behera, Dayanidhi
    Gowda, Nagaraj
    Iyer, Pravin
    JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2021, 9 : A889 - A889
  • [29] Active Immunotherapy With Prostvac® Demonstrates Potent Anti-tumor Efficacy in a Mouse Model of Prostate Cancer
    Rountree, Ryan B.
    Mandl, Stefanie J.
    Cote, Joseph
    dela Cruz, Tracy
    Giffon, Thierry
    Gordon, Evan
    Foy, Susan P.
    Lombardo, John R.
    Trent, Erica
    Laus, Reiner
    Delcayre, Alain
    JOURNAL OF IMMUNOTHERAPY, 2012, 35 (09) : 772 - 773
  • [30] Engineering armored TCR-modified T cells to enhance anti-tumor efficacy.
    Drakes, Dylan J.
    Rafiq, Sarwish
    Purdon, Terence
    Brentjens, Renier
    CANCER IMMUNOLOGY RESEARCH, 2020, 8 (04) : 56 - 57