Tandem CD19/CD22 Dual Targets CAR TCells Bridging Hematopoietic Stem Cells Transplantation Acquires Robust Remission for Relapsed and Refractory B Acute Lymphoblastic Leukemia Patients

被引：2
|
作者：
Cui, Wei [1 ]
Zhang, Xinyue [1 ]
Dai, Haiping [1 ]
Cui, Qingya [1 ]
Yin, Jia [1 ]
Li, Zheng [1 ]
Yu, Lei [2 ]
Kang, Liqing [2 ]
Wu, Depei [1 ]
Tang, Xiaowen [1 ]
机构：
[1] Soochow Univ, Affiliated Hosp 1, Jiangsu Inst Hematol, Natl Clin Res Ctr Hematol Dis, Suzhou, Peoples R China
[2] Shanghai Unicar Therapy Biomed Technol Co Ltd, Shanghai, Peoples R China
来源：
BLOOD | 2021年 / 138卷
关键词：
D O I：
10.1182/blood-2021-152565
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
1753
引用
收藏
页数：3
相关论文
共 50 条
  • [31] Immunotoxins against CD19 and CD22 are effective in killing precursor-B acute lymphoblastic leukemia cells in vitro
    Herrera, L
    Farah, RA
    Pellegrini, VA
    Aquino, DB
    Sandler, ES
    Buchanan, GR
    Vitetta, ES
    LEUKEMIA, 2000, 14 (05) : 853 - 858
  • [32] Decitabine-primed tandem CD19/CD22 CAR-T therapy in relapsed/refractory diffuse large B-cell lymphoma patients
    Qu, Changju
    Zou, Rui
    Wang, Peng
    Zhu, Qian
    Kang, Liqing
    Ping, Nana
    Xia, Fan
    Liu, Hailing
    Kong, Danqing
    Yu, Lei
    Wu, Depei
    Jin, Zhengming
    FRONTIERS IN IMMUNOLOGY, 2022, 13
  • [33] CAR T cells with dual targeting of CD19 and CD22 in adult patients with recurrent or refractory B cell malignancies: a phase 1 trial
    Spiegel, Jay Y.
    Patel, Shabnum
    Muffly, Lori
    Hossain, Nasheed M.
    Oak, Jean
    Baird, John H.
    Frank, Matthew J.
    Shiraz, Parveen
    Sahaf, Bita
    Craig, Juliana
    Iglesias, Maria
    Younes, Sheren
    Natkunam, Yasodha
    Ozawa, Michael G.
    Yang, Eric
    Tamaresis, John
    Chinnasamy, Harshini
    Ehlinger, Zach
    Reynolds, Warren
    Lynn, Rachel
    Rotiroti, Maria Caterina
    Gkitsas, Nikolaos
    Arai, Sally
    Johnston, Laura
    Lowsky, Robert
    Majzner, Robbie G.
    Meyer, Everett
    Negrin, Robert S.
    Rezvani, Andrew R.
    Sidana, Surbhi
    Shizuru, Judith
    Weng, Wen-Kai
    Mullins, Chelsea
    Jacob, Allison
    Kirsch, Ilan
    Bazzano, Magali
    Zhou, Jing
    Mackay, Sean
    Bornheimer, Scott J.
    Schultz, Liora
    Ramakrishna, Sneha
    Davis, Kara L.
    Kong, Katherine A.
    Shah, Nirali N.
    Qin, Haiying
    Fry, Terry
    Feldman, Steven
    Mackall, Crystal L.
    Miklos, David B.
    NATURE MEDICINE, 2021, 27 (08) : 1419 - +
  • [34] Efficacy and safety of CD19 CAR-T cell therapy for acute lymphoblastic leukemia patients relapsed after allogeneic hematopoietic stem cell transplantation
    Cao, Xing-Yu
    Li, Jing-Jing
    Lu, Pei-Hua
    Liu, Kai-Yan
    INTERNATIONAL JOURNAL OF HEMATOLOGY, 2022, 116 (03) : 315 - 329
  • [35] CAR T cells with dual targeting of CD19 and CD22 in adult patients with recurrent or refractory B cell malignancies: a phase 1 trial
    Jay Y. Spiegel
    Shabnum Patel
    Lori Muffly
    Nasheed M. Hossain
    Jean Oak
    John H. Baird
    Matthew J. Frank
    Parveen Shiraz
    Bita Sahaf
    Juliana Craig
    Maria Iglesias
    Sheren Younes
    Yasodha Natkunam
    Michael G. Ozawa
    Eric Yang
    John Tamaresis
    Harshini Chinnasamy
    Zach Ehlinger
    Warren Reynolds
    Rachel Lynn
    Maria Caterina Rotiroti
    Nikolaos Gkitsas
    Sally Arai
    Laura Johnston
    Robert Lowsky
    Robbie G. Majzner
    Everett Meyer
    Robert S. Negrin
    Andrew R. Rezvani
    Surbhi Sidana
    Judith Shizuru
    Wen-Kai Weng
    Chelsea Mullins
    Allison Jacob
    Ilan Kirsch
    Magali Bazzano
    Jing Zhou
    Sean Mackay
    Scott J. Bornheimer
    Liora Schultz
    Sneha Ramakrishna
    Kara L. Davis
    Katherine A. Kong
    Nirali N. Shah
    Haiying Qin
    Terry Fry
    Steven Feldman
    Crystal L. Mackall
    David B. Miklos
    Nature Medicine, 2021, 27 : 1419 - 1431
  • [36] Efficacy and safety of CD19 CAR-T cell therapy for acute lymphoblastic leukemia patients relapsed after allogeneic hematopoietic stem cell transplantation
    Xing-yu Cao
    Jing-jing Li
    Pei-hua Lu
    Kai-yan Liu
    International Journal of Hematology, 2022, 116 : 315 - 329
  • [37] Phase I Trial Using CD19/CD22 Bispecific CAR T Cells in Pediatric and Adult Acute Lymphoblastic Leukemia (ALL)
    Schultz, Liora M.
    Muffly, Lori S.
    Spiegel, Jay Y.
    Ramakrishna, Sneha
    Hossain, Nasheed
    Baggott, Christina
    Sahaf, Bita
    Patel, Shabnum
    Craig, Juliana
    Yoon, Jenny
    Kadapakkam, Meena
    Majzner, Robbie G.
    Frank, Matthew J.
    Erickson, Courtney
    Marcy, Anne Cunniffe
    Fujimoto, Michelle
    Bhatia, Neehar
    Meyer, Everett H.
    Kong, Katherine A.
    Egeler, Emily
    Mavroukakis, Sharon
    Qin, Haiying
    Fry, Terry J.
    Feldman, Steven A.
    Miklos, David B.
    Mackall, Crystal L.
    Davis, Kara L.
    BLOOD, 2019, 134
  • [38] CD19 and CD22-directed biespecific CAR for B-cell Acute Lymphoblastic Leukemia
    Zanetti, S. R.
    Velasco-Hernandez, T.
    Gutierrez-Aguera, F.
    Roca-Ho, H.
    Sanchez-Martinez, D.
    Petazzi, P.
    Torres, R.
    Molina, O.
    Torrebadell-Burriel, M.
    Vidriales-Vicente, M. B.
    Hrusak, O.
    Fuster, J. L.
    Juan, M.
    Bueno, C.
    Menendez, P.
    HUMAN GENE THERAPY, 2019, 30 (11) : A54 - A54
  • [39] Sequential treatment with anti-CD19 and CD22 chimeric antigen receptor T cells in children with relapsed or refractory B acute lymphoblastic leukemia
    Chanut, Mathilde
    HEMATOLOGIE, 2023, 29 (06): : 332 - 334
  • [40] Early Clinical Experience of CD19 x CD22 Dual Specific CAR T Cells for Enhanced Anti-Leukemic Targeting of Acute Lymphoblastic Leukemia
    Gardner, Rebecca
    Annesley, Colleen
    Finney, Olivia
    Summers, Corinne
    Lamble, Adam J.
    Rivers, Julie
    Crews, Kaelin
    Huang, Lauren
    Brown, Christopher
    Mgebroff, Stephanie
    Lindgren, Catherine
    Spratt, Karen
    Gustafson, Josh
    Johnson, Adam
    Park, Julie R.
    Jensen, Michael C.
    BLOOD, 2018, 132
12345