Improved Synthesis of Monoprotected 5-and 6-Amino-2-azanorbornanes

被引：1

作者：

Dacenko, Oleksandr P. ^{[2
]}

Manoylenko, Olga V. ^{[2
]}

Grygorenko, Oleksandr O. ^{[1
,2
]}

Mykhailiuk, Pavel K. ^{[1
,2
]}

Volochnyuk, Dmitriy M. ^{[2
]}

Shishkin, Oleg V. ^{[3
]}

Tolmachev, Andrey A. ^{[1
,2
]}

机构：

[1] Kyiv Natl Taras Shevchenko Univ, Dept Chem, UA-01033 Kiev, Ukraine

[2] Enamine Ltd, Kiev, Ukraine

[3] Natl Acad Sci Ukraine, STC Inst Single Crystals, Kharkov, Ukraine

来源：

SYNTHETIC COMMUNICATIONS | 2011年 / 41卷 / 07期

关键词：

Bicyclic compounds; cycloadditions; diamines; molecular rigidity; peptidomimetics;

D O I：

10.1080/00397911003707196

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[image omitted] An improved synthesis of Boc-monoprotected 5- and 6-amino-2-azanorbornanes is reported. The synthetic scheme consists of five steps and allows multigram quantities of the title compounds to be obtained. The regio- and stereochemistries of the products are established by two-dimensional NMR experiments.

引用

页码：981 / 992

页数：12

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