Initial Presentation of Acute Lymphoblastic Leukemia with Osteoporosis and Multiple Spontaneous Bone Fractures

被引:0
|
作者
Cohan, N. [1 ]
Sarikhani, S. [2 ]
Moslemi, S. [2 ]
Karimi, M. [1 ]
机构
[1] Shiraz Univ Med Sci, Hematol Res Ctr, Nemazee Hosp, Shiraz, Iran
[2] Shiraz Univ Med Sci, Coll Med, Shiraz, Iran
关键词
Acute lymphoblastic leukemia; Osteoporosis; Bone fracture; Iran; CHILDHOOD LEUKEMIA; FARS PROVINCE; SOUTHERN IRAN;
D O I
暂无
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Acute lymphoblastic leukemia (ALL) is the most common childhood malignancy. Skeletal abnormalities have been described in association with ALL including osteoprosis and bone fractures. Different factors including the disease itself or soluble products of malignant cells and treatment agents like cytotoxic drugs, methotroxate, corticosteroids and radiotherapy may be responsible for defective bone homeostasis in these patients. Orthopedic conditions and pain may be the first manifestation of acute leukemia and it is important for physicians to recognize the skeletal manifestation of acute childhood leukemia because of a delay in diagnosis has adverse effect on survival. We present a child with ALL that refer with multi bone fractures as a first manifestation of the disease.
引用
收藏
页码:52 / 54
页数:3
相关论文
共 50 条
  • [31] Eosinophilic presentation of acute lymphoblastic leukemia
    Rezamand, Azim
    Ghorashi, Ziaaedin
    Ghorashi, Soria
    Nezami, Nariman
    AMERICAN JOURNAL OF CASE REPORTS, 2013, 14 : 143 - 146
  • [32] Hypoplastic presentation of acute lymphoblastic leukemia
    Tharmalingam, Hannah
    Naresh, Kikkeri
    Bain, Barbara J.
    Pavlu, Jiri
    AMERICAN JOURNAL OF HEMATOLOGY, 2012, 87 (07) : 702 - 702
  • [33] Initial presentation as sclerotic bone metastases in a patient with acute myelogenous leukemia
    Wang, Yongjin
    Chow, Edward
    Piliotis, Eugenia
    Tsao, May
    JOURNAL OF PALLIATIVE MEDICINE, 2007, 10 (01) : 256 - 259
  • [34] Proptosis as Initial Presentation of Acute Lymphoblastic Leukemia in a Child with no associated symptoms: A Case Report
    Goudarzipour, Kourosh
    Mohammadi, Ahmad
    Taherian, Reza
    Ahmadi, Mehran Arab
    Behnam, Behdad
    Yazdi, Niloofar Ayoobi
    IRANIAN JOURNAL OF PEDIATRIC HEMATOLOGY AND ONCOLOGY, 2020, 10 (01) : 69 - 73
  • [35] Obstructive Jaundice due to Pancreatic Involvement as an Initial Presentation of Adult Acute Lymphoblastic Leukemia
    Oladiran, Oreoluwa
    Nwosu, Ifeanyi
    CASE REPORTS IN HEMATOLOGY, 2018, 2018
  • [36] Hypercalcemia As the Sole Initial Presentation of Precursor B-cell Acute Lymphoblastic Leukemia
    Kumar, Anup Kumar Trikannad Ashwini
    Vellanki, Sruthi
    Krishnamoorthy, Geetha
    CUREUS JOURNAL OF MEDICAL SCIENCE, 2022, 14 (02)
  • [37] Prolonged lumbosacral pain as the initial presentation in acute lymphoblastic leukemia in an adult A case report
    Li, Fanglin
    Wang, Jinxia
    Liu, Aifei
    Xin, Liuyan
    Zhong, Sisi
    Hong, Yang
    Chen, Yijian
    MEDICINE, 2019, 98 (24)
  • [38] Type B Lactic Acidosis: A Rare Initial Presentation of Childhood Acute Lymphoblastic Leukemia
    Narayani, S.
    Balu, P.
    Santhanam, R.
    Scott, J. X.
    INDIAN JOURNAL OF NEPHROLOGY, 2019, 29 (01) : 71 - +
  • [39] Ischaemic optic neuropathy induced sudden blindness as an initial presentation of acute lymphoblastic leukemia
    Chaudhuri, Tamojit
    Roy, Somnath
    Roy, Parag
    INDIAN JOURNAL OF MEDICAL AND PAEDIATRIC ONCOLOGY, 2013, 34 (04) : 335 - +
  • [40] Osteolytic Bone Lesions As an Initial Presenting Manifestation of Acute Lymphoblastic Leukemia in Adults
    Al-Mashdali, Abdulrahman F.
    Yassin, Mohamed A.
    BLOOD, 2022, 140 : 11603 - 11604