AMPK Activity: A Primary Target for Diabetes Prevention with Therapeutic Phytochemicals

被引:23
|
作者
Chung, Min-Yu [1 ]
Choi, Hyo-Kyoung [1 ]
Hwang, Jin-Taek [1 ,2 ]
机构
[1] Korea Food Res Inst, Personalized Diet Res Grp, Jeonju 55365, South Korea
[2] Univ Sci & Technol, Dept Food Biotechnol, Daejeon 34113, South Korea
关键词
diabetes; AMP-activated protein kinase; medicinal plants; ingredient; ACTIVATED PROTEIN-KINASE; STIMULATES GLUCOSE-UPTAKE; SKELETAL-MUSCLE CELLS; MITOCHONDRIAL BIOGENESIS; NATURAL-PRODUCT; BLOOD-GLUCOSE; PGC-1; ALPHA; BETA-CELLS; INSULIN; MECHANISMS;
D O I
10.3390/nu13114050
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Diabetes is a metabolic syndrome characterized by inadequate blood glucose control and is associated with reduced quality of life and various complications, significantly shortening life expectancy. Natural phytochemicals found in plants have been traditionally used as medicines for the prevention of chronic diseases including diabetes in East Asia since ancient times. Many of these phytochemicals have been characterized as having few side effects, and scientific research into the mechanisms of action responsible has accumulated mounting evidence for their efficacy. These compounds, which may help to prevent metabolic syndrome disorders including diabetes, act through relevant intracellular signaling pathways. In this review, we examine the anti-diabetic efficacy of several compounds and extracts derived from medicinal plants, with a focus on AMP-activated protein kinase (AMPK) activity.
引用
收藏
页数:13
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