Prenylated indole alkaloids from co-culture of marine-derived fungi Aspergillus sulphureus and Isaria felina

被引：35

作者：

Afiyatullov, Shamil Sh. ^{[1
]}

Zhuravleva, Olesya I. ^{[1
,2
]}

Antonov, Alexandr S. ^{[1
]}

Berdyshev, Dmitrii V. ^{[1
]}

Pivkin, Mikhail V. ^{[1
]}

Denisenko, Vladimir A. ^{[1
]}

Popov, Roman S. ^{[1
]}

Gerasimenko, Andrey V. ^{[3
]}

von Amsberg, Gunhild ^{[4
]}

Dyshlovoy, Sergey A. ^{[1
,2
,4
]}

Leshchenko, Elena V. ^{[1
,2
]}

Yurchenko, Anton N. ^{[1
,2
]}

机构：

[1] Russian Acad Sci, Far Eastern Branch, GB Elyakov Pacific Inst Bioorgan Chem, Vladivostok, Russia

[2] Far Eastern Fed Univ, Vladivostok, Russia

[3] Russian Acad Sci, Far Eastern Branch, Inst Chem, Vladivostok, Russia

[4] Univ Med Ctr Hamburg Eppendorf, Lab Expt Oncol, Dept Oncol Hematol & Bone Marrow Transplantat, Sect Pneumol,Hubertus Wald Tumorzentrum, Hamburg, Germany

来源：

JOURNAL OF ANTIBIOTICS | 2018年 / 71卷 / 10期

关键词：

PROSTATE-CANCER; NATURAL-PRODUCTS; F-K; POLYKETIDES; DERIVATIVES; RESISTANCE;

D O I：

10.1038/s41429-018-0072-9

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Five new prenylated indole alkaloids, 17-hydroxynotoamide D (1), 17-O-ethylnotoamide M (2), 10-O-acetylsclerotiamide (3), 10-O-ethylsclerotiamide (4), and 10-O-ethylnotoamide R (5) were isolated from a co-culture of marine-derived fungi Aspergillus sulphureus KMM 4640 and Isaria felina KMM 4639. The structures of 1-5 were determined by detailed analysis of spectroscopic data and by comparison with related known compounds. The absolute configurations of 1-5 were determined by time-dependent density functional theory (TD-DFT) calculations of ECD spectra. Compound 2 is able to inhibit the colony formation of human prostate cancer cells 22Rv1 at non-cytotoxic concentration of 10 mu M.

引用

页码：846 / 853

页数：8

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