A Case of T-cell Acute Lymphoblastic Leukemia Relapsed As Myeloid Acute Leukemia

被引：8

作者：

Paganin, Maddalena ^{[1
]}

Buldini, Barbara ^{[2
]}

Germano, Giuseppe ^{[3
]}

Seganfreddo, Elena ^{[2
]}

di Meglio, Annamaria ^{[3
]}

Magrin, Elisa ^{[2
]}

Grillo, Francesca ^{[2
]}

Pigazzi, Martina ^{[2
,3
]}

Rizzari, Carmelo ^{[4
]}

Cazzaniga, Giovanni ^{[4
]}

Khiabanian, Hossein ^{[5
,6
]}

Palomero, Teresa ^{[7
,8
]}

Rabadan, Raul ^{[5
,6
]}

Ferrando, Adolfo A. ^{[7
,8
,9
]}

Basso, Giuseppe ^{[2
]}

机构：

[1] Azienda Osped Padova, Clin Oncoematol Pediat, Padua, Italy

[2] Univ Padua, Dipartimento Salute Donna & Bambino, Padua, Italy

[3] Fdn Citta Speranza, Lab Oncoematol Pediat, Ist Ric Pediat, Fifth Floor,Corso Stati Uniti 4, I-35127 Padua, Italy

[4] Univ Milan, Ctr Ric Tettamanti, Clin Pediat, Milan, Italy

[5] Columbia Univ, Dept Syst Biol, New York, NY USA

[6] Columbia Univ, Dept Biomed Informat, New York, NY USA

[7] Columbia Univ, Inst Canc Genet, New York, NY USA

[8] Columbia Univ, Dept Pathol, New York, NY USA

[9] Columbia Univ, Dept Pediat, New York, NY 10027 USA

来源：

PEDIATRIC BLOOD & CANCER | 2016年 / 63卷 / 09期

关键词：

switch lineage; T-ALL; whole-exome sequencing; ACTIVATING MUTATIONS; LINEAGE SWITCH; CHEMOTHERAPY; TRANSPLANT; AIEOP;

D O I：

10.1002/pbc.26054

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A 4-year-old male with the diagnosis of T-cell acute lymphoblastic leukemia (T-ALL) relapsed after 19 months with an acute myeloid leukemia (AML). Immunoglobulin and T-cell receptor gene rearrangements analyses reveal that both leukemias were rearranged with a clonal relationship between them. Comparative genomic hybridization (Array-CGH) and whole-exome sequencing analyses of both samples suggest that this leukemia may have originated from a common T/myeloid progenitor. The presence of homozygous deletion of p16/INK4A, p14/ARF, p15/INK4B, and heterozygous deletion of WT1 locus remained stable in the leukemia throughout phenotypic switch, revealing that this AML can be genetically associated to T-ALL.

引用

页码：1660 / 1663

页数：4

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