Solid-state Characterization of Bifonazole - beta-cyclodextrin Binary Systems. II

被引：0

作者：

Trandafirescu, Cristina ^{[1
]}

Avram, Stefana ^{[1
]}

Soica, Codruta ^{[1
]}

Aigner, Zoltan ^{[2
]}

Arpad, Gyeresi ^{[3
]}

Kata, Mihaly ^{[2
]}

Dehelean, Cristina ^{[1
]}

Szabadai, Zoltan ^{[1
]}

Borcan, Florin ^{[1
]}

机构：

[1] Victor Babe Univ Med & Pharm, Fac Pharm, Timisoara 300041, Romania

[2] Univ Szeged, Fac Pharm, Szeged, Hungary

[3] Univ Med & Pharm, Fac Pharm, Targu Mures 540142, Romania

来源：

REVISTA DE CHIMIE | 2014年 / 65卷 / 11期

关键词：

bifonazole; beta-cyclodextrin; inclusion complex; SOLUBILIZATION; COMPLEXES;

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Continuing our previous researches, this paper presents the studies regarding the solid state characterization of binary systems between antimycotic bifonazole and beta-cyclodextrin. The binary systems were prepared in two (bifonazole : beta-cyclodextrin) molar ratios, 1:2 and 1:3, using the physical mixture and the kneading method. In order to characterize the solid state interaction between the two components, hot-stage microscopy, differential scanning calorimetry, X-ray diffractometry and Fourier-transformed infrared spectroscopy were used. The analysis performed indicate a molecular interaction between the components due to a partially encapsulation of bifonazole into the cyclodextrin cavity.

引用

页码：1336 / 1339

页数：4

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