Solid-state Characterization of Bifonazole - beta-cyclodextrin Binary Systems. II

被引：0
|
作者：
Trandafirescu, Cristina [1 ]
Avram, Stefana [1 ]
Soica, Codruta [1 ]
Aigner, Zoltan [2 ]
Arpad, Gyeresi [3 ]
Kata, Mihaly [2 ]
Dehelean, Cristina [1 ]
Szabadai, Zoltan [1 ]
Borcan, Florin [1 ]
机构：
[1] Victor Babe Univ Med & Pharm, Fac Pharm, Timisoara 300041, Romania
[2] Univ Szeged, Fac Pharm, Szeged, Hungary
[3] Univ Med & Pharm, Fac Pharm, Targu Mures 540142, Romania
来源：
REVISTA DE CHIMIE | 2014年 / 65卷 / 11期
关键词：
bifonazole; beta-cyclodextrin; inclusion complex; SOLUBILIZATION; COMPLEXES;
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Continuing our previous researches, this paper presents the studies regarding the solid state characterization of binary systems between antimycotic bifonazole and beta-cyclodextrin. The binary systems were prepared in two (bifonazole : beta-cyclodextrin) molar ratios, 1:2 and 1:3, using the physical mixture and the kneading method. In order to characterize the solid state interaction between the two components, hot-stage microscopy, differential scanning calorimetry, X-ray diffractometry and Fourier-transformed infrared spectroscopy were used. The analysis performed indicate a molecular interaction between the components due to a partially encapsulation of bifonazole into the cyclodextrin cavity.
引用
收藏
页码：1336 / 1339
页数：4
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