Dental Biofilm Microbiota Dysbiosis Is Associated With the Risk of Acute Graft-Versus-Host Disease After Allogeneic Hematopoietic Stem Cell Transplantation
被引:19
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作者:
Heidrich, Vitor
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机构:
Hosp Sirio Libanes, Ctr Oncol Mol, Sao Paulo, Brazil
Univ Sao Paulo, Inst Quim, Dept Bioquim, Sao Paulo, BrazilHosp Sirio Libanes, Ctr Oncol Mol, Sao Paulo, Brazil
Heidrich, Vitor
[1
,2
]
Bruno, Julia S.
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机构:
Hosp Sirio Libanes, Ctr Oncol Mol, Sao Paulo, BrazilHosp Sirio Libanes, Ctr Oncol Mol, Sao Paulo, Brazil
Bruno, Julia S.
[1
]
Knebel, Franciele H.
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机构:
Hosp Sirio Libanes, Ctr Oncol Mol, Sao Paulo, BrazilHosp Sirio Libanes, Ctr Oncol Mol, Sao Paulo, Brazil
Knebel, Franciele H.
[1
]
de Molla, Vinicius C.
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h-index: 0
机构:
Hosp Sirio Libanes, Ctr Oncol, Sao Paulo, Brazil
Univ Fed Sao Paulo, Dept Oncol Clin & Expt, Sao Paulo, BrazilHosp Sirio Libanes, Ctr Oncol Mol, Sao Paulo, Brazil
de Molla, Vinicius C.
[3
,4
]
Miranda-Silva, Wanessa
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Hosp Sirio Libanes, Ctr Oncol Mol, Sao Paulo, BrazilHosp Sirio Libanes, Ctr Oncol Mol, Sao Paulo, Brazil
Miranda-Silva, Wanessa
[1
]
Asprino, Paula F.
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Hosp Sirio Libanes, Ctr Oncol Mol, Sao Paulo, BrazilHosp Sirio Libanes, Ctr Oncol Mol, Sao Paulo, Brazil
Asprino, Paula F.
[1
]
Tucunduva, Luciana
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机构:
Hosp Sirio Libanes, Ctr Oncol, Sao Paulo, BrazilHosp Sirio Libanes, Ctr Oncol Mol, Sao Paulo, Brazil
Tucunduva, Luciana
[3
]
Rocha, Vanderson
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h-index: 0
机构:
Hosp Sirio Libanes, Ctr Oncol, Sao Paulo, Brazil
Univ Sao Paulo, Hosp Clin, Fac Med, Inst Canc Estado Sao Paulo ICESP, Sao Paulo, Brazil
Churchill Hosp, Natl Hlth Serv Blood & Transplant, Oxford, EnglandHosp Sirio Libanes, Ctr Oncol Mol, Sao Paulo, Brazil
Rocha, Vanderson
[3
,5
,6
]
Novis, Yana
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机构:
Hosp Sirio Libanes, Ctr Oncol, Sao Paulo, BrazilHosp Sirio Libanes, Ctr Oncol Mol, Sao Paulo, Brazil
Novis, Yana
[3
]
Arrais-Rodrigues, Celso
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机构:
Hosp Sirio Libanes, Ctr Oncol, Sao Paulo, Brazil
Univ Fed Sao Paulo, Dept Oncol Clin & Expt, Sao Paulo, BrazilHosp Sirio Libanes, Ctr Oncol Mol, Sao Paulo, Brazil
Arrais-Rodrigues, Celso
[3
,4
]
Fregnani, Eduardo R.
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机构:
Hosp Sirio Libanes, Ctr Oncol, Sao Paulo, BrazilHosp Sirio Libanes, Ctr Oncol Mol, Sao Paulo, Brazil
Fregnani, Eduardo R.
[3
]
Camargo, Anamaria A.
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机构:
Hosp Sirio Libanes, Ctr Oncol Mol, Sao Paulo, BrazilHosp Sirio Libanes, Ctr Oncol Mol, Sao Paulo, Brazil
Camargo, Anamaria A.
[1
]
机构:
[1] Hosp Sirio Libanes, Ctr Oncol Mol, Sao Paulo, Brazil
[2] Univ Sao Paulo, Inst Quim, Dept Bioquim, Sao Paulo, Brazil
[3] Hosp Sirio Libanes, Ctr Oncol, Sao Paulo, Brazil
[4] Univ Fed Sao Paulo, Dept Oncol Clin & Expt, Sao Paulo, Brazil
[5] Univ Sao Paulo, Hosp Clin, Fac Med, Inst Canc Estado Sao Paulo ICESP, Sao Paulo, Brazil
Acute graft-versus-host disease (aGVHD) is one of the major causes of death after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Recently, aGVHD onset was linked to intestinal microbiota (IM) dysbiosis. However, other bacterial-rich gastrointestinal sites, such as the mouth, which hosts several distinctive microbiotas, may also impact the risk of GVHD. The dental biofilm microbiota (DBM) is highly diverse and, like the IM, interacts with host cells and modulates immune homeostasis. We characterized changes in the DBM of patients during allo-HSCT and evaluated whether the DBM could be associated with the risk of aGVHD. DBM dysbiosis during allo-HSCT was marked by a gradual loss of bacterial diversity and changes in DBM genera composition, with commensal genera reductions and potentially pathogenic bacteria overgrowths. High Streptococcus and high Corynebacterium relative abundance at preconditioning were associated with a higher risk of aGVHD (67% vs. 33%; HR = 2.89, P = 0.04 and 73% vs. 37%; HR = 2.74, P = 0.04, respectively), while high Veillonella relative abundance was associated with a lower risk of aGVHD (27% vs. 73%; HR = 0.24, P < 0.01). Enterococcus faecalis bloom during allo-HSCT was observed in 17% of allo-HSCT recipients and was associated with a higher risk of aGVHD (100% vs. 40%; HR = 4.07, P < 0.001) and severe aGVHD (60% vs. 12%; HR = 6.82, P = 0.01). To the best of our knowledge, this is the first study demonstrating that DBM dysbiosis is associated with the aGVHD risk after allo-HSCT.
机构:
So Med Univ, Nanfang Hosp, Dept Hematol, Guangzhou, Guangdong, Peoples R ChinaSo Med Univ, Nanfang Hosp, Dept Hematol, Guangzhou, Guangdong, Peoples R China
Liu, Qifa, Sr.
Ling, Yiwen
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机构:
So Med Univ, Nanfang Hosp, Dept Hematol, Guangzhou, Guangdong, Peoples R ChinaSo Med Univ, Nanfang Hosp, Dept Hematol, Guangzhou, Guangdong, Peoples R China
Ling, Yiwen
Fan, Zhiping
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机构:
So Med Univ, Nanfang Hosp, Dept Hematol, Guangzhou, Guangdong, Peoples R ChinaSo Med Univ, Nanfang Hosp, Dept Hematol, Guangzhou, Guangdong, Peoples R China
Fan, Zhiping
Zhang, Yu
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机构:
So Med Univ, Nanfang Hosp, Dept Hematol, Guangzhou, Guangdong, Peoples R ChinaSo Med Univ, Nanfang Hosp, Dept Hematol, Guangzhou, Guangdong, Peoples R China
Zhang, Yu
Huang, Fen
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机构:
So Med Univ, Nanfang Hosp, Dept Hematol, Guangzhou, Guangdong, Peoples R ChinaSo Med Univ, Nanfang Hosp, Dept Hematol, Guangzhou, Guangdong, Peoples R China
Huang, Fen
Wu, Xiuli
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机构:
So Med Univ, Nanfang Hosp, Dept Hematol, Guangzhou, Guangdong, Peoples R ChinaSo Med Univ, Nanfang Hosp, Dept Hematol, Guangzhou, Guangdong, Peoples R China
Wu, Xiuli
Xuan, Li
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机构:
So Med Univ, Nanfang Hosp, Dept Hematol, Guangzhou, Guangdong, Peoples R ChinaSo Med Univ, Nanfang Hosp, Dept Hematol, Guangzhou, Guangdong, Peoples R China
Xuan, Li
Wu, Meiqing
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机构:
So Med Univ, Nanfang Hosp, Dept Hematol, Guangzhou, Guangdong, Peoples R ChinaSo Med Univ, Nanfang Hosp, Dept Hematol, Guangzhou, Guangdong, Peoples R China
机构:
Childrens Hosp Los Angeles, Childrens Ctr Canc & Blood Dis, Div Hematol Oncol & Blood & Marrow Transplantat, Los Angeles, CA USA
4650 Sunset Blvd,Mailstop 54, Los Angeles, MS 90027 USAChildrens Hosp Los Angeles, Childrens Ctr Canc & Blood Dis, Div Hematol Oncol & Blood & Marrow Transplantat, Los Angeles, CA USA
Gray, Ashley N.
Defilipp, Zachariah
论文数: 0引用数: 0
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机构:
Massachusetts Gen Hosp, Hematopoieit Cell Transplant & Cell Therapy Progra, Boston, MA USAChildrens Hosp Los Angeles, Childrens Ctr Canc & Blood Dis, Div Hematol Oncol & Blood & Marrow Transplantat, Los Angeles, CA USA