Dental Biofilm Microbiota Dysbiosis Is Associated With the Risk of Acute Graft-Versus-Host Disease After Allogeneic Hematopoietic Stem Cell Transplantation

被引:19
|
作者
Heidrich, Vitor [1 ,2 ]
Bruno, Julia S. [1 ]
Knebel, Franciele H. [1 ]
de Molla, Vinicius C. [3 ,4 ]
Miranda-Silva, Wanessa [1 ]
Asprino, Paula F. [1 ]
Tucunduva, Luciana [3 ]
Rocha, Vanderson [3 ,5 ,6 ]
Novis, Yana [3 ]
Arrais-Rodrigues, Celso [3 ,4 ]
Fregnani, Eduardo R. [3 ]
Camargo, Anamaria A. [1 ]
机构
[1] Hosp Sirio Libanes, Ctr Oncol Mol, Sao Paulo, Brazil
[2] Univ Sao Paulo, Inst Quim, Dept Bioquim, Sao Paulo, Brazil
[3] Hosp Sirio Libanes, Ctr Oncol, Sao Paulo, Brazil
[4] Univ Fed Sao Paulo, Dept Oncol Clin & Expt, Sao Paulo, Brazil
[5] Univ Sao Paulo, Hosp Clin, Fac Med, Inst Canc Estado Sao Paulo ICESP, Sao Paulo, Brazil
[6] Churchill Hosp, Natl Hlth Serv Blood & Transplant, Oxford, England
来源
FRONTIERS IN IMMUNOLOGY | 2021年 / 12卷
基金
巴西圣保罗研究基金会;
关键词
oral microbiota; supragingival plaque; microbiome dysbiosis; acute GVHD; allogeneic HSCT; bone marrow transplant; GUT MICROBIOME; ORAL MICROBIOME; COLONIZATION; INHIBITION; DIVERSITY; PATHOGENS; DIAGNOSIS; BACTERIA; PROJECT; GVHD;
D O I
10.3389/fimmu.2021.692225
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Acute graft-versus-host disease (aGVHD) is one of the major causes of death after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Recently, aGVHD onset was linked to intestinal microbiota (IM) dysbiosis. However, other bacterial-rich gastrointestinal sites, such as the mouth, which hosts several distinctive microbiotas, may also impact the risk of GVHD. The dental biofilm microbiota (DBM) is highly diverse and, like the IM, interacts with host cells and modulates immune homeostasis. We characterized changes in the DBM of patients during allo-HSCT and evaluated whether the DBM could be associated with the risk of aGVHD. DBM dysbiosis during allo-HSCT was marked by a gradual loss of bacterial diversity and changes in DBM genera composition, with commensal genera reductions and potentially pathogenic bacteria overgrowths. High Streptococcus and high Corynebacterium relative abundance at preconditioning were associated with a higher risk of aGVHD (67% vs. 33%; HR = 2.89, P = 0.04 and 73% vs. 37%; HR = 2.74, P = 0.04, respectively), while high Veillonella relative abundance was associated with a lower risk of aGVHD (27% vs. 73%; HR = 0.24, P < 0.01). Enterococcus faecalis bloom during allo-HSCT was observed in 17% of allo-HSCT recipients and was associated with a higher risk of aGVHD (100% vs. 40%; HR = 4.07, P < 0.001) and severe aGVHD (60% vs. 12%; HR = 6.82, P = 0.01). To the best of our knowledge, this is the first study demonstrating that DBM dysbiosis is associated with the aGVHD risk after allo-HSCT.
引用
收藏
页数:11
相关论文
共 50 条
  • [1] Late Acute Graft-versus-Host Disease after Allogeneic Hematopoietic Stem Cell Transplantation
    Omer, Aazim K.
    Weisdorf, Daniel J.
    Lazaryan, Aleksandr
    Shanley, Ryan
    Blazar, Bruce R.
    MacMillan, Margaret L.
    Brunstein, Claudio
    Bejanyan, Nelli
    Arora, Mukta
    BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 2016, 22 (05) : 879 - 883
  • [2] Microbiota Predict Infections and Acute Graft-Versus-Host Disease After Pediatric Allogeneic Hematopoietic Stem Cell Transplantation
    Margolis, Elisa B.
    Alfaro, Gabriela Maron
    Sun, Yilun
    Dallas, Ronald H.
    Allison, Kim J.
    Ferrolino, Jose
    Ross, Hailey S.
    Davis, Amy E.
    Jia, Qidong
    Turner, Paige
    Mackay, Victoria
    Morin, Cara E.
    Triplett, Brandon M.
    Klein, Eileen J.
    Englund, Janet A.
    Tang, Li
    Hayden, Randall T.
    JOURNAL OF INFECTIOUS DISEASES, 2023, 228 (05): : 627 - 636
  • [3] Biological advances in acute graft-versus-host disease after allogeneic hematopoietic stem cell transplantation
    Duran-Struuck, Raimon
    Reddy, Pavan
    TRANSPLANTATION, 2008, 85 (03) : 303 - 308
  • [4] Angiogenic factors are associated with development of acute graft-versus-host disease after allogeneic hematopoietic stem cell transplantation
    Nie, Di-min
    Wu, Qiu-ling
    Zhu, Xia-xia
    Zhang, Ran
    Zheng, Peng
    Fang, Jun
    You, Yong
    Zhong, Zhao-dong
    Xia, Ling-hui
    Hong, Mei
    JOURNAL OF HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY-MEDICAL SCIENCES, 2015, 35 (05) : 694 - 699
  • [5] Angiogenic Factors Are Associated with Development of Acute Graft-Versus-Host Disease after Allogeneic Hematopoietic Stem Cell Transplantation
    聂第敏
    吴秋玲
    朱夏夏
    张然
    郑鹏
    方俊
    游泳
    仲照东
    夏凌辉
    洪梅
    Journal of Huazhong University of Science and Technology(Medical Sciences), 2015, 35 (05) : 694 - 699
  • [6] Angiogenic factors are associated with development of acute graft-versus-host disease after allogeneic hematopoietic stem cell transplantation
    Di-min Nie
    Qiu-ling Wu
    Xia-xia Zhu
    Ran Zhang
    Peng Zheng
    Jun Fang
    Yong You
    Zhao-dong Zhong
    Ling-hui Xia
    Mei Hong
    Journal of Huazhong University of Science and Technology [Medical Sciences], 2015, 35 : 694 - 699
  • [7] Angiogenic Factors Are Associated with Development of Acute Graft-Versus-Host Disease after Allogeneic Hematopoietic Stem Cell Transplantation
    聂第敏
    吴秋玲
    朱夏夏
    张然
    郑鹏
    方俊
    游泳
    仲照东
    夏凌辉
    洪梅
    Current Medical Science, 2015, (05) : 694 - 699
  • [8] Analyses of risk factors for intestinal acute graft-versus-host disease after allogeneic hematopoietic stem cell transplantation
    燕法红
    ChinaMedicalAbstracts(InternalMedicine), 2014, 31 (01) : 53 - 53
  • [9] Monocytes As an Early Risk Factor for Acute Graft-Versus-Host Disease after Allogeneic Hematopoietic Stem Cell Transplantation
    Sun, Huimin
    Hao, Sha
    Dong, Fang
    Wu, Linjie
    Zhao, Xueying
    Cheng, Tao
    BLOOD, 2024, 144 : 7370 - 7371
  • [10] Monocytes as an early risk factor for acute graft-versus-host disease after allogeneic hematopoietic stem cell transplantation
    Sun, Huimin
    Wu, Linjie
    Zhao, Xueying
    Huo, Yingying
    Dong, Peiyuan
    Pang, Aiming
    Zheng, Yawei
    Han, Yiwen
    Ma, Shihui
    Jiang, Erlie
    Dong, Fang
    Cheng, Tao
    Hao, Sha
    FRONTIERS IN IMMUNOLOGY, 2024, 15