Epstein-Barr virus in patients with persistent lymphadenopathy

被引:0
|
作者
Melikyan, A. L. [1 ]
Garanzha, T. A. [1 ]
Tikhomirov, D. S. [1 ]
Kaplanskaya, I. B. [1 ]
Varlamova, E. Yu [1 ]
Kovalyova, L. G. [1 ]
Filatov, F. P. [1 ]
机构
[1] Hematol Res Ctr, Moscow, Russia
来源
GEMATOLOGIYA I TRANSFUZIOLOGIYA | 2007年 / 52卷 / 04期
关键词
stubborn lymphadenopathy; Epstein-Barr virus; serological diagnosis; immunohistochemistry;
D O I
暂无
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
A retrospective analysis of clinical laboratory findings in 62 patients with persistent relapsing lymphadenopathy of obscure etiology was carried out. Virus-specific markers of active infection (IgM-VCA, IgG-EA) or a previous infection caused by Epstein-Barr virus (EBV) (EgG-EBNA-1) were detected in the serum of 57 patients. Positive staining of histological preparations of biopsy specimens of the lymph nodes by EBV-specific antibodies to EBNA-2 indicated the fact of EBV infection but did not characterize the infection phase. A criteria for evaluating the activity of EBV infection during other than the active period is suggested. An inverse relationship between the level of beta-globulins and level of IgG-EBNA-1 antibodies was detected, which can serve as a marker of immunodeficiency in EBV infection.
引用
收藏
页码:21 / 27
页数:7
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