Ultrastructural analysis of neuronal synapses using state-of-the-art nano-imaging techniques

被引：10

作者：

Tao, Changlu ^{[1
,2
]}

Xia, Chenglong ^{[1
,2
]}

Chen, Xiaobing ^{[3
]}

Zhou, Z. Hong ^{[1
,2
,4
]}

Bi, Guoqiang ^{[1
,2
]}

机构：

[1] Univ Sci & Technol China, Ctr Integrat Imaging, Hefei Natl Lab Phys Sci Microscale, Hefei 230027, Peoples R China

[2] Univ Sci & Technol China, Sch Life Sci, Hefei 230027, Peoples R China

[3] NINDS, Neurobiol Lab, NIH, Bethesda, MD 20892 USA

[4] Univ Calif Los Angeles, Dept Microbiol Immunol & Mol Genet, Los Angeles, CA 90095 USA

来源：

NEUROSCIENCE BULLETIN | 2012年 / 28卷 / 04期

基金：

中国国家自然科学基金;

关键词：

synaptic architecture; nano-imaging; super-resolution imaging; STED microscopy; STORM; PALM; cryoET; TRANSMISSION ELECTRON-MICROSCOPY; CELL-ADHESION MOLECULES; CRYOELECTRON TOMOGRAPHY; POSTSYNAPTIC DENSITY; FLUORESCENCE MICROSCOPY; LIGHT-MICROSCOPY; 3-DIMENSIONAL STRUCTURE; BIOLOGICAL SPECIMENS; DIFFRACTION BARRIER; STIMULATED-EMISSION;

D O I：

10.1007/s12264-012-1249-z

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Neuronal synapses are functional nodes in neural circuits. Their organization and activity define an individual's level of intelligence, emotional state and mental health. Changes in the structure and efficacy of synapses are the biological basis of learning and memory. However, investigation of the molecular architecture of synapses has been impeded by the lack of efficient techniques with sufficient resolution. Recent developments in state-of-the-art nano-imaging techniques have opened up a new window for dissecting the molecular organization of neuronal synapses with unprecedented resolution. Here, we review recent technological advances in nano-imaging techniques as well as their applications to the study of synapses, emphasizing super-resolution light microscopy and 3-dimensional electron tomography.

引用

页码：321 / 332

页数：12

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