Isolation and Structural Elucidation of Cyclic Tetrapeptides from Onychocola sclerotica

被引：23

作者：

Perez-Victoria, Ignacio ^{[1
]}

Martin, Jesus ^{[1
]}

Gonzalez-Menendez, Victor ^{[1
]}

de Pedro, Nuria ^{[1
]}

El Aouad, Noureddine ^{[1
]}

Javier Ortiz-Lopez, Francisco ^{[1
]}

Ruben Tormo, Jose ^{[1
]}

Platas, Gonzalo ^{[1
]}

Vicente, Francisca ^{[1
]}

Bills, Gerald F. ^{[1
]}

Genilloud, Olga ^{[1
]}

Goetz, Michael A. ^{[1
]}

Reyes, Fernando ^{[1
]}

机构：

[1] Fdn MEDINA, Ctr Excelencia Invest Med Innovadores Andalucia, E-18100 Granada, Spain

来源：

JOURNAL OF NATURAL PRODUCTS | 2012年 / 75卷 / 06期

关键词：

AMINO-ACIDS; MARINE; CHANNELS; FUNGI;

D O I：

10.1021/np3000987

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Three new cyclic tetrapeptides (1-3) have been isolated from the crude fermentation extract of Onychocola sclerotica. The planar structures of 1-3 were elucidated by detailed spectroscopic analyses using one- and two-dimensional NMR experiments and high-resolution mass spectrometry. The absolute configuration of the amino acid residues in each cyclotetrapeptide was established by Marfey's method. Compounds 1-3 displayed activity as cardiac calcium channel blockers (Cav1.2) but did not inhibit the hERG potassium channel and were not cytotoxic. These peptides are the first secondary metabolites ever reported from fungi of the order Arachnomycetales.

引用

页码：1210 / 1214

页数：5

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