Enzymatic method of preparation of optically active trans-2-amino cyclohexanol derivatives

被引：9
|
作者：
Ursini, A [1 ]
Maragni, P [1 ]
Bismara, C [1 ]
Tamburini, B [1 ]
机构：
[1] Glaxo Wellcome Inc, Res Ctr, Chem Dev Dept, Verona, Italy
来源：
SYNTHETIC COMMUNICATIONS | 1999年 / 29卷 / 08期
关键词：
D O I：
10.1080/00397919908086112
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Supported Lipase Amano PS-D catalyzes the resolution of (+/-)-trans-2-tert butoxycarbonyl amino cyclohexanol by a selective acylation reaction Using the supported enzyme gave a much faster reaction compared to existing methodology on similar substrates. A variety of acylating agents were investigated, with vinyl acetate providing the most practical and convenient procedure.
引用
收藏
页码：1369 / 1377
页数：9
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