Enzymatic method of preparation of optically active trans-2-amino cyclohexanol derivatives

被引：9

作者：

Ursini, A ^{[1
]}

Maragni, P ^{[1
]}

Bismara, C ^{[1
]}

Tamburini, B ^{[1
]}

机构：

[1] Glaxo Wellcome Inc, Res Ctr, Chem Dev Dept, Verona, Italy

来源：

SYNTHETIC COMMUNICATIONS | 1999年 / 29卷 / 08期

关键词：

D O I：

10.1080/00397919908086112

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Supported Lipase Amano PS-D catalyzes the resolution of (+/-)-trans-2-tert butoxycarbonyl amino cyclohexanol by a selective acylation reaction Using the supported enzyme gave a much faster reaction compared to existing methodology on similar substrates. A variety of acylating agents were investigated, with vinyl acetate providing the most practical and convenient procedure.

引用

页码：1369 / 1377

页数：9

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