Nanoemulsion delivery systems for oil-soluble vitamins: Influence of carrier oil type on lipid digestion and vitamin D3 bioaccessibility

被引：232
|
作者：
Ozturk, Bengu [1 ,2 ,5 ]
Argin, Sanem [3 ]
Ozilgen, Mustafa [3 ]
McClements, David Julian [1 ,4 ]
机构：
[1] Univ Massachusetts, Dept Food Sci, Chenoweth Lab, Amherst, MA 01003 USA
[2] Yeditepe Univ, Dept Chem Engn, Istanbul, Turkey
[3] Yeditepe Univ, Dept Food Engn, Istanbul, Turkey
[4] King Abdulaziz Univ, Prod Bioprod Ind Applicat Res Grp, Dept Biochem, Fac Sci, Jeddah 21589, Saudi Arabia
[5] TUBITAK Marmara Res Ctr, Food Inst, TR-41470 Gebze, Kocaeli, Turkey
来源：
FOOD CHEMISTRY | 2015年 / 187卷
基金：
美国农业部;
关键词：
Nanoemulsions; Vitamin D-3; Cholecalciferol; Calcifediol; Calcitriol; Digestion; Quillaja saponin; Carrier oil; Bioaccessibility; Bioavailability; IN-VITRO DIGESTION; BETA-CAROTENE BIOACCESSIBILITY; PROTEIN-STABILIZED EMULSIONS; QUILLAJA SAPONIN; CONTROLLED-RELEASE; D DEFICIENCY; BIOAVAILABILITY; FOOD; NUTRACEUTICALS; DIGESTIBILITY;
D O I：
10.1016/j.foodchem.2015.04.065
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
The influence of carrier oil type on the bioaccessibility of vitamin D-3 encapsulated within oil-in-water nanoemulsions prepared using a natural surfactant (quillaja saponin) was studied using a simulated gastrointestinal tract (GIT) model: mouth; stomach; small intestine. The rate of free fatty acid release during lipid digestion decreased in the following order: medium chain triglycerides (MCT) > corn oil approximate to fish oil > orange oil > mineral oil. Conversely, the measured bioaccessibility of vitamin D-3 decreased in the following order: corn oil approximate to fish oil > orange oil > mineral oil > MCT. These results show that carrier oil type has a considerable impact on lipid digestion and vitamin bioaccessibility, which was attributed to differences in the release of bioactives from lipid droplets, and their solubilization in mixed micelles. Nanoemulsions prepared using long chain triglycerides (corn or fish oil) were most effective at increasing vitamin bioaccessibility. (C) 2015 Elsevier Ltd. All rights reserved.
引用
收藏
页码：499 / 506
页数：8
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