Intercellular junctions and cellular polarity: the PAR-aPKC complex, a conserved core cassette playing fundamental roles in cell polarity

被引：359
|
作者：
Ohno, S [1 ]
机构：
[1] Yokohama City Univ, Sch Med, Dept Mol Biol, Kanazawa Ku, Yokohama, Kanagawa 2360004, Japan
来源：
CURRENT OPINION IN CELL BIOLOGY | 2001年 / 13卷 / 05期
关键词：
D O I：
10.1016/S0955-0674(00)00264-7
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Two PDZ-domain-containing adapter-like proteins, PAR-3 and PAR-6, and a protein kinase, atypical protein kinase C (PKC), cooperate together to establish cell polarity in a variety of biological contexts. These include asymmetric cell division in early Caenorhabditis elegans embryo and Drosophila neuroblasts, as well as the establishment and maintenance of apical-basal polarity in Drosophila and mammalian epithelial cells. Recent studies on the role of this PAR-aPKC complex in epithelia[ cell polarization provide new insights into the molecular basis of epithelial junctional formation and cell polarity.
引用
收藏
页码：641 / 648
页数：8
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