Cell polarity: the ups and downs of the Par6/aPKC complex

被引：93
|
作者：
Henrique, D
Schweisguth, F
机构：
[1] Fac Med Lisbon, Inst Mol Med, P-1649028 Lisbon, Portugal
[2] Ecole Normale Super, CNRS, UMR 8542, F-75230 Paris, France
来源：
CURRENT OPINION IN GENETICS & DEVELOPMENT | 2003年 / 13卷 / 04期
关键词：
D O I：
10.1016/S0959-437X(03)00077-7
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
A signaling complex in which atypical protein kinase C associates with a regulatory protein, Par6, plays an essential role in establishing cell polarity. Recent studies in organisms ranging from worms to mammals have highlighted some of the conserved mechanisms by which the assembly, localization and activity of this complex are regulated. Recent work is also beginning to unravel how this complex acts in concert with additional molecular complexes to establish and maintain polarity.
引用
收藏
页码：341 / 350
页数：10
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