The extraction and infrared identification of Gamma-hydroxybutyric acid (GHB) from aqueous solutions

被引:0
|
作者
Chappell, JS [1 ]
Meyn, AW [1 ]
Ngim, KK [1 ]
机构
[1] Drug Enforcement Adm, Western Lab, San Francisco, CA 94105 USA
关键词
forensic science; gamma-hydroxybutyric acid; gamma-hydroxybutyrate; gamma-butyrolactone; GHB; GBL; infrared spectroscopy; liquid-liquid extraction;
D O I
暂无
中图分类号
DF [法律]; D9 [法律]; R [医药、卫生];
学科分类号
0301 ; 10 ;
摘要
The chemical analysis of gamma-hydroxybutyric acid (GHB) in most forensic laboratories is complicated by the highly polar nature of the GHB molecule, which makes it unsuitable for direct analysis by gas chromatography (GC). Consequently, a popular analytical approach is to convert GHB into the corresponding lactone or a derivative compound that is then identified by mass spectrometry employed in conjunction with GC (GC/MS). An alternative approach is presented here where GHB may be isolated as a free acid specie from complex aqueous solutions employing a liquid-liquid extraction technique. This approach can yield a relatively pure residue of GHB that presents an infrared transmission spectrum that is sufficiently distinct for identification purposes. Infrared spectroscopy (IR) is a very popular technique that is available to most crime laboratories. The liquid-liquid extraction behavior of GHB is examined in detail and the uniqueness of the infrared spectrum is discussed.
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页码:52 / 59
页数:8
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